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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
ISBN: 9781337408332

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
ISBN: 9781337408332
Textbook Problem
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Effect of MDMA on Neural Development Animal studies are often used to assess effects of prenatal exposure to illicit drugs. For example, Jack Lipton used rats to study the behavioral effect of prenatal exposure to MDMA, the active ingredient in the drug commonly called Ecstasy. He injected female rats with either MDMA or saline solution when they were 14 to 20 days pregnant. This is the period when their offsprings’·brains were forming. When those offspring were 21 days old, Lipton tested their ability to adjust to a new environment. He placed each young rat in a new cage and used a photobeam system to record how much each rat moved around before settling down. FIGURE 32.15 shows his results.

Chapter 32, Problem 1DAA, Effect of MDMA on Neural Development Animal studies are often used to assess effects of prenatal

FIGURE 32.15 Effect of prenatal exposure to MDMA on rats. Young (21-day-old) rats were place in an unfamiliar cage. Movements were detected when the rat interrupted a photobeam. Rats were monitored at 5-minute interval for a total of 20 minutes. Blue bars are average numbers of photobeam breaks for rats whose mothers received saline; red bars are for rats whose mothers received MDMA.

Which rats moved around most (caused the most photobeam breaks) during the first 5 minutes in a new cage those prenatally exposed to MDMA or the controls?

Summary Introduction

To determine: The rat which moved around most during the first five minutes in a new cage, those prenatally exposed to MDMA or the controls.

Introduction: Ecstasy is a psychedelic drug. The active ingredient present in ecstasy is 3, 4-Methylenedioxyamphetamine (MDMA). It is commonly used as a recreational drug.

Explanation

The study on the rats was performed to assess the behavioral effects of the prenatal exposure of MDMA to their offspring. Researcher J injected female rats with either MDMA or saline solution from day 14 to day 20. When the offspring was 21 days old, they were tested for their ability to adjust in the new environment for a period of 20 minutes at an interval of 5 minutes (0-5 min, 6-10 min, 11-15 min, and 16-20 min). The movement was detected by a photobeam system.

Refer to Fig. 32.15, “Effect of prenatal exposure to MDMA on rats’’ in the question. During the first five minutes, the rat that was injected with normal saline moved more than the rat that was injected with MDMA.

Conclusion

During the first five minutes, the rats those were prenatally exposed to saline moved around more than those exposed to MDMA.

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