Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 32, Problem 22P
Interpretation Introduction
To propose:
Using the Active Model for c-Abl kinase, explain how Gleevec functions as a therapy for chronic myelogenous patients.
Introduction:
Specific inherited mutations in BRCA1 and BRCA2 most notably increase the risk of female breast and ovarian cancers, but they have also been linked with increased risks of numerous additional kinds of cancer. A harmful BRCA1 or BRCA2 mutation can be inherited from a person's mother or father.
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CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that might enhance the inhibition of ATCase?
Suggest what might be the actual cause of the various pathologies characterizing mevalonate kinase deficiency.
Functional and structural analysis indicates that Gleevec is an ATPcompetitive inhibitor of the Bcr-Abl kinase. In fact, many kinase inhibitors under investigation or currently marketed as drugs are ATP competitive. Can you suggest a potential drawback of drugs that utilize this particular mechanism of action?
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ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning