In a mixture, penicillin is determined by mixing of 14 C labeled compound of amount 0.981mg. The specific activity of 14 C labeled compound is 5.42 × 10 3 c p m / m g . The pure crystalline penicillin of amount 0.406mg was isolated after the equilibrium state. The net activity of the material is 343cpm. The mass of the penicillin in the sample is to be determined. Concept introduction: The mass of the penicillin is calculated by the following formula- m x = R t R m × m m − m t ………………… (1) Where, m x = mass of inactive sample R t = counting rate R m = counting rate of inactive analyte m m = isolated mass which is purified from the mixture of radioactive tracer m t = mass of radioactive tracer

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Principles of Instrumental Analysis

7th Edition
Douglas A. Skoog + 2 others
Publisher: Cengage Learning
ISBN: 9781305577213
BuyFind

Principles of Instrumental Analysis

7th Edition
Douglas A. Skoog + 2 others
Publisher: Cengage Learning
ISBN: 9781305577213

Solutions

Chapter 32, Problem 32.15QAP
Interpretation Introduction

Interpretation:

In a mixture, penicillin is determined by mixing of 14C labeled compound of amount 0.981mg. The specific activity of 14C labeled compound is 5.42×103cpm/mg. The pure crystalline penicillin of amount 0.406mg was isolated after the equilibrium state. The net activity of the material is 343cpm. The mass of the penicillin in the sample is to be determined.

Concept introduction:

The mass of the penicillin is calculated by the following formula-

mx=RtRm×mmmt ………………… (1)

Where,

mx = mass of inactive sample

Rt = counting rate

Rm = counting rate of inactive analyte

mm = isolated mass which is purified from the mixture of radioactive tracer

mt = mass of radioactive tracer

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