Biology: The Unity and Diversity o...

15th Edition

Cecie Starr + 3 others

ISBN: 9781337408332

Textbook Problem

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Effect of MDMA on Neural Development Animal studies are often used to assess effects of prenatal exposure to illicit drugs. For example, Jack Lipton used rats to study the behavioral effect of prenatal exposure to MDMA, the active ingredient in the drug commonly called Ecstasy. He injected female rats with either MDMA or saline solution when they were 14 to 20 days pregnant. This is the period when their offsprings’·brains were forming. When those offspring were 21 days old, Lipton tested their ability to adjust to a new environment. He placed each young rat in a new cage and used a photobeam system to record how much each rat moved around before settling down. FIGURE 32.15 shows his results.

FIGURE 32.15 Effect of prenatal exposure to MDMA on rats. Young (21-day-old) rats were place in an unfamiliar cage. Movements were detected when the rat interrupted a photobeam. Rats were monitored at 5-minute interval for a total of 20 minutes. Blue bars are average numbers of photobeam breaks for rats whose mothers received saline; red bars are for rats whose mothers received MDMA.

Does this study support the hypothesis that MDMA affects a developing rat's brain?

Summary Introduction

To determine: Whether this study support the hypothesis that MDMA affects a developing rat’s brain.

Concept introduction: Ecstasy is a psychedelic drug. Its active ingredient is 3,4-Methylenedioxyamphetamine (MDMA). It is commonly used as a recreational drug.

Explanation

The study on rat was performed to assess the behavioral effects of prenatal exposure of MDMA to their offspring. Researcher J injected a female rat with either MDMA or a saline solution from day 14 to day 20. When the offspring were 21 days old, they were tested for their ability to adjust to the new environment (in a new cage) for a period of 20 minutes at an interval of 5 minutes (0-5 min, 6-10 min, 11-15 min, and 16-20 min). The movement was detected by a photo beam system.

Refer to Fig. 32.15 “Effect of prenatal exposure to MDMA on rats’’ in the question, the rat injected with only saline showed photobeam break of 123...

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Biology: The Unity and Diversity o...

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Biology Biology: The Unity and Diversity of Life (MindTap Course List)15th Edition