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Cholera is a disease caused by bacteria that make cholera toxin. In the presence of this toxin, chloride ion channels in cells of the small intestine lining are stuck in their open position. As a result, an excess of chloride ions (Cl − ) flows from these cells into the lumen of the small intestine. Movement of Cl − creates a charge gradient, so sodium ions (Na + ) also flow into the lumen. Explain why the movement of these ions into the lumen results in the life-threatening diarrhea that characterizes cholera.

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
BuyFind

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

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Chapter 39, Problem 4CT
Textbook Problem

Cholera is a disease caused by bacteria that make cholera toxin. In the presence of this toxin, chloride ion channels in cells of the small intestine lining are stuck in their open position. As a result, an excess of chloride ions (Cl) flows from these cells into the lumen of the small intestine. Movement of Cl creates a charge gradient, so sodium ions (Na+) also flow into the lumen. Explain why the movement of these ions into the lumen results in the life-threatening diarrhea that characterizes cholera.

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