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A proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. Based on the following data, the counselor constructs a pedigree encompassing three generations: (1) The maternal grandfather of the proband has the disease. (2) The mother of the proband is unaffected and is the youngest of five children, the three oldest being male. (3) The proband has an affected older sister, but the youngest siblings are unaffected twins (boy and girl). (4) All the individuals who have the disease have been revealed. Duplicate the counselor’s feat

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 4, Problem 10QP
Textbook Problem
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A proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. Based on the following data, the counselor constructs a pedigree encompassing three generations:

  1. (1) The maternal grandfather of the proband has the disease.
  2. (2) The mother of the proband is unaffected and is the youngest of five children, the three oldest being male.
  3. (3) The proband has an affected older sister, but the youngest siblings are unaffected twins (boy and girl).
  4. (4) All the individuals who have the disease have been revealed. Duplicate the counselor’s feat

Summary Introduction

To sketch: The pedigree chart for a proband from the data provided.

Introduction: A pedigree chart is a diagram that shows the occurrence and appearance of a particular trait or phenotypes of a particular gene in a family from one generation to the next. Pedigree charts are used to keep track of generations in animal breedings. Additionally, pedigree charts are also used in humans to understand the probability of a child having a particular disorder.

Explanation of Solution

Pedigree charts have been used by the experts to understand the probability of the child having a particular disorder of a condition that has an occurrence in the family.

Pictorial representation: Fig 1 represents the pedigree of the proband. The males are represented in square boxes whereas the females are shown by circles, and the individual with the disease is represented by shading. Disease-free individuals are represented by empty boxes and circles. II.4 is unknown; hence represent in the form of diamond...

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