Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 4, Problem 14QP
Analysis of Autosomal Recessive and Dominant Traits
Huntington disease is a rare, fatal disease that usually develops in the fourth or fifth decade of life. It is caused by a single autosomal dominant allele. A
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Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia.
1. Give the genotypes of Jillian and Jacob.
Assuming that they will have 4 children, what is the probability that:
2. all their children will be normal?
3. they will have a son with Huntington’s disease?
4. they will have a daughter inflicted with both conditions
Neo-Mendelian Genetics: Complete dominance and overdominance
Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia.
What are the genotypes of Mary and Paul?
If they plan to have four children, what is the probability that:
all their children will be normal? ____________
they will have a son with Huntington’s disease? ___________
they will have a daughter inflicted with both conditions?____________
MODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. The Mendelian pattern of inheritance is a general term that refers to any pattern of inheritance in which traits do not segregate in accordance with Mendel’s lawsII. As an example, a characteristic may be controlled by one gene with two alleles, but the two alleles have a same relationship like the simple dominant-recessive relationship
a. The first statement (I) is correct and the second statement (II) is wrong
b. The first statement (I) is wrong and the second statement (II) is correct
c. Both statements are correct
d. Both statements are wrong
MODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. The continuity of life from one cell to another has its foundation in the reproduction of cells by way of the cell cycle.II. The cell cycle is an orderly sequence of events in the life of a cell from the division of a single parent cell to produce…
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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- Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Describe the phenotype and primary gene or protein defect of the X-linked recessive disease muscular dystrophy.arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?arrow_forward
- Analysis of X-Linked Dominant and Recessive Traits The following is a pedigree for a common genetic trait. Analyze the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forwardAnalysis of X-Linked Dominant and Recessive Traits A young boy is color-blind. His one brother and five sisters are not. The boy has three maternal uncles and four maternal aunts. None of his uncles children or grandchildren is color-blind. One of the maternal aunts married a color-blind man, and half of her children, both male and female, are color-blind. The other aunts married men who have normal color vision. All their daughters have normal vision, but half of their sons are color-blind. a. Which of the boys four grandparents transmitted the gene for color blindness? b. Are any of the boys aunts or uncles color-blind? c. Is either of the boys parents color-blind?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Does the indicated individual (III-5) show the trait in question?arrow_forward
- Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forwardAnalysis of Autosomal Recessive and Dominant Traits In the following pedigree, assume that the father of the proband is homozygous for a rare trait. What pattern of inheritance is consistent with this pedigree? In particular, explain the phenotype of the proband.arrow_forwardCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky mucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helped the afflicted to live through adulthood. The mother of Claudia died from cystic fibrosis, but her father was normal and never had any relative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that: a. all children will be normal b. at least two will be normal PLEASE SHOW COMPLETE SOLUTIONarrow_forward
- Background Information: Autosomal Dominant/Recessive- The trait is encoded by a single genetic locus with two segregating alleles: One dominant (A) and one recessive (a). The locus is not on a sex chromosome, and is not linked to any other trait unless specified.Autosomal Codominance- This mode is the same as Autosomal Dominant/Recessive, except that neither allele isdominant or recessive and heterozygous individuals have a distinct phenotype. X-linked Dominant/Recessive - The trait is encoded by a single genetic locus with two segregating alleles: One dominant (A) and one recessive (a). The locus is located on the X-chromosome, and is not linked to any other trait unless specified.X-linked Codominance- This is the same as X-linked dominant/recessive, except that heterozygous females (twocopies of the X-chromosome) experience a distinct phenotype relative to females that are homozygous for either of the two alleles. Males will be segregating with two phenotypes (because they only have…arrow_forwardMODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. The law of segregation states that the two alleles for a heritable character separate during gamete formation and end up in a same gamete.II. The law of dominance states that one of the pairs of inherited traits will be dominant and the others recessive unless both the factors are recessive a. The first statement (I) is correct and the second statement (II) is wrong b. The first statement (I) is wrong and the second statement (II) is correct c. Both statements are correct d. Both statements are wrong MODIFIED TRUE OR FALSE. In the following items, read each statement carefully. I. Ecosystem is defined as the geographic area where plants, animals, and other organisms, as well as weather and landscape, work together to form a bubble of life.II. This system consists of a regularly interacting and interdependent components forming a unified whole. a. The first…arrow_forwardPompe disease is a glycogen storage disorder caused by a lack of ⍺-glucosidase, the enzyme that converts glycogen to glucose in the muscles. Babies born with this disorder die by the age of two. Pompe disease is a genetic disorder caused by the presence of two recessive autosomal alleles. A man and a woman heterozygous for the condition have two female unaffected children. Determine the probability, expressed as a whole number percentage, of a third baby being born a male with Pompe disease. Your answer must include the use of a Punnett square as well as a legend indicating the allele symbols used. (2 marks)arrow_forward
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