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Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 4, Problem 5QP
Textbook Problem
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Analysis of Autosomal Recessive and Dominant Traits

  1.       a.            What pattern of inheritance is suggested by the following pedigree?

Chapter 4, Problem 5QP, Analysis of Autosomal Recessive and Dominant Traits  a. What pattern of inheritance is suggested by

  1.       b.            For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.

a.

Summary Introduction

To explain: The pattern of inheritance in the given pedigree chart.

Introduction: The genes can be inherited either in a dominant or recessive manner. If both the alleles of the gene are dominant, the individual is called homozygous dominant. Similarly, if an individual has two recessive alleles of the same gene, the individual is called autosomal recessive. However, an individual having one dominant and one recessive allele is known as heterozygous.

Explanation of Solution

The pattern of inheritance suggested by the given pedigree is autosomal dominant. In the autosomal dominant condition, it is important to have atleast one non-functional allele of the gene. In the given pedigree, the male is affected, which signifies the diseased condition.

There are 50% of people in each generation that are affected, so it is likely to be an autosomal dominant condition...

b.

Summary Introduction

To explain: The complete pedigree for the autosomal dominant trait in which male is heterozygous in the first generation.

Introduction: Genetic disorders are characterized by the abnormalities in the level of gene expression. These disorders are generally inherited from one generation to another. However, in many cases, these disorders can be acquired. The transmission of these disorders is studied through pedigree analysis.

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