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Use the following information to respond to the three questions posed below: (1) The proband (affected individual who led to the construction of the pedigree) exhibits the trait. (2) Neither her husband nor her only sibling, an older brother, exhibits the trait. (3) The proband has five children by her current husband. The oldest is a boy, followed by a girl, then another boy, and then identical twin girls. Only the second oldest fails to exhibit the trait. (4) Both parents of the proband show the trait. a. Construct a pedigree of the trait in this family. b. Determine how the trait is inherited (go step by step to examine each possible pattern of inheritance). c. Can you deduce the genotype of the proband’s husband for this trait?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 4, Problem 7QP
Textbook Problem
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Use the following information to respond to the three questions posed below: (1) The proband (affected individual who led to the construction of the pedigree) exhibits the trait. (2) Neither her husband nor her only sibling, an older brother, exhibits the trait. (3) The proband has five children by her current husband. The oldest is a boy, followed by a girl, then another boy, and then identical twin girls. Only the second oldest fails to exhibit the trait. (4) Both parents of the proband show the trait.

  1. a. Construct a pedigree of the trait in this family.
  2. b. Determine how the trait is inherited (go step by step to examine each possible pattern of inheritance).
  3. c. Can you deduce the genotype of the proband’s husband for this trait?

a.

Summary Introduction

To sketch: a pedigree chart for the proband with the given data.

Introduction: A pedigree chart shows the occurrence and appearance of a particular trait or phenotypes of a particular gene in a family from one generation to the next. Pedigree charts are used to keep track of generations in animal breeding. Additionally, pedigree charts are also used in humans to understand the probability of a child having a particular disorder

Explanation of Solution

Pedigree charts have been used by the experts to understand the probability of the child having a particular disorder of a condition that has an occurrence in the family. These charts help us to understand the movement of the traits from generation to generation.

Pictorial representation: Fig 1 represents the pedigree chart of the affected proband. The shaded boxes and circles represent affected individuals. Females are shown by circles and males are shown by rectangles...

b.

Summary Introduction

To determine: The type of inheritance of the trait.

Introduction: Traits or phenotypes can be inherited in multiple ways.

  • Sex-linked inheritance: this occurs when the trait is on the X or Y chromosome. Males give X chromosome to all daughter and Y to all sons. And mother gives X chromosome to both sons and daughters. If the trait is present on the X chromosome, then all the sons are affected, while only 50% daughter will show the trait.
  • Paternal inheritance: This happens when the gene is present on the Y chromosome. In this case, since Y chromosome is directly passed to the sons, if the father is affected all the sons will show the trait.
  • Maternal inheritance: This happens when the gene is carried in the mitochondrial genome. Since the children get their mitochondria from the mother, all the children will be affected in this case.

c.

Summary Introduction

To determine: The genotype of the proband’s husband for the trait in question.

Introduction: Every trait or gene has two alleles. Some genes are recessive, that is they need to be homozygous to express or show the phenotype. However, some alleles are dominant, These alleles can express themselves even in heterozygous states.

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