Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 4, Problem 8QP
Analysis of Autosomal Recessive and Dominant Traits
In the following pedigree, assume that the father of the proband is homozygous for a rare trait. What pattern of inheritance is consistent with this pedigree? In particular, explain the
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Inheritance regarding two un+linked genes, two loci with separate alleles from the mother, and two alleles from the father that results in an organism's genotype for those specific genes.
A hereditary disease exists among humans called phenylketonuria, which is an autosomal recessive mutant allele. The father is homozygous for this condition where the mother is a carrier. The father is also bow-legged and heterozygote for this trait where the mother has straight legs.
a.) show parents genotype for these two traits
b.) Their first child was a daughter with straight legs and phenylketonuria. What was the probability for that to occur?
c.) What was the probability that her future siblings were to be a brother and a sister (no particular order of sex) who are carriers of the disease and the brother to be bow-legged whilst the sister having straight legs?
d.) If adding the blood types of the parents where the father is AB and the mother to be A. What is the probability for this couple to…
Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).
Mendel genetics and how meiosis plays into the law of segration and law of independent assortment in simple terms?
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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- Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?arrow_forward
- Y-linked Inheritance. One trait that is Y-linked is hypertrichosis of the ears. Suppose a man with hypertrichosis marries and has children, what is the chance of his sons getting the trait? His daughters? Why?arrow_forwardWhy inversion heterozygotes produce few if any recombinant progeny.arrow_forwardAutosomal Recessive Inheritance (trait only expressed if homozygous recessive)An albino man (nn) marries a normally pigmented woman (N_) who has an albino mother. What is the chance that their children will be albino?arrow_forward
- GENETICS In a sexually reproducing diploid organism in which 2n=6, a normal meiocyte in reduction should exhibit a total of 3 bivalents at the metaphase plate. Consider the following organism in the previous statement. if there is no crossing over, the number of possible haploids (gamete) genotypes generated by "chromosome shuffling" during meiosis is _____?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Using the following pedigree, deduce a compatible pattern of inheritance. Identify the genotype of the individual in question.arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forward
- Variations on a Theme by Mendel Pea plants usually have white or red flowers. A strange pea-plant variant is found that has pink flowers. A selfcross of this plant yields the following phenotypes: 30 red flowers 62 pink flowers 33 white flowers What are the genotypes of the parents? What is the genotype of the progeny with red flowers?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits The X and Y chromosomes are structurally and genetically distinct. However, they do pair during meiosis at a small region near the tips of their short arms, indicating that the chromosomes are homologous in this region. If a gene lies in this region, will its pattern of transmission be more like that of a sex-linked gene or an autosomal gene? Why?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Does the indicated individual (III-5) show the trait in question?arrow_forward
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