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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892

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BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892
Textbook Problem

Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. The study below compares the effects of two different types of capsules used to administer the drug to patients (GITS—red line, and Cotracten X—blue line). Each graph shows changes with time following initial administra- tion of the capsules. Figure A compares the levels of nifedipine in the blood with each capsule type. The ability of the different cap- sules to reduce workload on the heart by altering blood pressure or heart rate is shown in Figures B and C, respectively.

Chapter 44, Problem 1ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  1

Chapter 44, Problem 1ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  2

Chapter 44, Problem 1ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  3

Are elevated plasma levels of nifedipine(above 10 ng/mL) required for the drug to perform its actions?

Source: M. J. Brown and C. B. Toal. 2008. Formulation of long-acting nifedipine tablets influences the heart rate and sympathetic nervous system response in hypertensive patients. British Journal of Clinical Pharmacology 65:646–652.

Summary Introduction

To review:

Based on the given data, we have to examine the requirement of increased levels of nifedipine (above 10 ng/mL) drug to perform its actions.

Introduction:

Nifedine is a group of drugs and is also called calcium channel blocker whose function is to relax the muscles of heart, and the blood vessels. Also, this drug is used for the treatment of hypertension or the high blood pressure and angina or the chest pain. A person suffering from hypertension needs to be on this medication under doctoral advice. The chart represents the effect of drug Nifedipine (more than 10 ng/mL) in a patient on plasma level with respect to time.

Biology: The Dynamic Science (MindTap Course List), Chapter 44, Problem 1ITD

Explanation

From the given graph, it can be estimated that there is no requirement of drug Nifedipine (above 10 ng/mL) to perform its function because the capsule GITS showed its effect on lesser concentration, which is below than 10 ng/mL and the drug Cotracten X showed its response when its concentration is 10 ng/ml on plasma.

The drug Contracten X starts responding in 1.5 hours from the time of its exposure on plasma while the other drug GITS starts showing its effect after 3 hours from the time of drug exposure...

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