(a) Interpretation: Formation of hemoglobin α 2 β 2 quaternary structure is affected by amino acid because of which changes occur in mutant globin. During the study of tertiary structure, changes occur in amino acid in mutant globin needs to be determined. Concept Introduction : Gene encoding concept which is called a mutation will be used. It takes place due to change in the DNA gene that alters the genetic information carried by it. Mutagen is known to be an agent of the substance which is responsible for the permanent alteration in the physical composition of a DNA gene.

BuyFind

Biochemistry

6th Edition
Reginald H. Garrett + 1 other
Publisher: Cengage Learning
ISBN: 9781305577206
BuyFind

Biochemistry

6th Edition
Reginald H. Garrett + 1 other
Publisher: Cengage Learning
ISBN: 9781305577206

Solutions

Chapter 5, Problem 16P
Interpretation Introduction

(a)

Interpretation:

Formation of hemoglobin α2 β2 quaternary structure is affected by amino acid because of which changes occur in mutant globin. During the study of tertiary structure, changes occur in amino acid in mutant globin needs to be determined.

Concept Introduction :

Gene encoding concept which is called a mutation will be used. It takes place due to change in the DNA gene that alters the genetic information carried by it. Mutagen is known to be an agent of the substance which is responsible for the permanent alteration in the physical composition of a DNA gene.

Interpretation Introduction

(b)

Interpretation:

The tendency of polymerizing into very large structure hemoglobin tetramers is increased by other mutation such as S-form of the β-globin chain. Substitution place of amino acid in these mutants needs to be determined.

Concept Introduction :

Mutation takes place due to change in the DNA gene that alters the genetic information carried by it. Mutagen is known to be an agent of the substance which is responsible for the permanent alteration in the physical composition of a DNA gene.

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