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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 6, Problem 16QP
Textbook Problem
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Assume that a meiotic-nondisjunction event causes trisomy 8 in a newborn. If two of the three copies of chromosome 8 are absolutely identical, at what point during meiosis did the nondisjunction event take place?

Summary Introduction

To describe: The precise stage of meiosis during which nondisjunction results in trisomy 8.

Introduction: Nondisjunction is an error usually occurs during cell division. It results in chromosomal abnormality. Chromosome disorders can be divided into two categories: abnormalities in chromosome number and chromosome structural rearrangements. Even small segments of chromosomes can span many genes. Chromosomal disorders are characteristically dramatic and often fatal.

Explanation of Solution

Pictorial representation Fig.1 represents nondisjunction in meiosis-I and meiosis-II.

Fig.1: Nondisjunction in meiosis-I and meiosis-II.

In meiosis-I, an event of crossing over takes place in which hybrid chromosomes are formed. Nondisjunction in meiosis leads to the formation of four gametes in which two have 24 chromosomes, and two have 22 chromosomes...

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