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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 6, Problem 19QP
Textbook Problem
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The majority of nondisjunction events leading to Down syndrome are maternal in origin. Based on the duration of meiosis in females, speculate on the possible reasons for females contributing aneuploid gametes more frequently than males do.

Summary Introduction

To describe: The reasons for females contributing aneuploid gametes more than males in the case of Down syndrome.

Introduction: Gametes are the cells that are produced by an organism which are used to produce a new zygote (an individual organism). Male gametes are comparatively smaller than female gametes. Gametes carry half genetic material which completes on the fusion of the male and female gametes.

Explanation of Solution

With the increasing age of women, the chances of aneuploid pregnancy increases. This is because women’s eggs are as old. Females have all of their eggs in the fetal stage and therefore, they are born with all the eggs they will have in their lifetime. In the case of males, the sperm is made every 65-75 days. Therefore, it is not as old as an egg. According to the theory of aneuploidy, the chromosomes in the eggs are less likely to divide properly leading to eggs having an extra or missing chromosome.

This can be stated as, “Females have limited number of gametes and these gametes are called oocytes...

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