To match: The term from the column A to the correct description in the column B. Introduction: B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Question

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Answer 1

Question

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

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Answer 2

Question

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

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Answer 3

Question

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

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Answer 4

Question

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

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Answer 5

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Answer 6

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Answer 7

Chapter 6, Problem 1Q

Summary Introduction

To match:

The term from the column A to the correct description in the column B.

Introduction:

B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.

Answer 8

Expert Solution & Answer

Answer to Problem 1Q

The table below represents the correct match from the Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cell	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Explanation of Solution

Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.

Answer 12

Conclusion

The table below represents the correct match from Column A to Column B.

Column A	Column B
a. Immature B-cell	4. μ heavy chain plus λ or κ light chains on cell surface
b. Small pre-B-cell	1. V-J rearranging
c. Large pre-B-cells	5. VDJ rearranged but light-chain gene in germline configuration
d. Stem cell	2. germline configuration of heavy- and light-chain genes
e. Early pro-B-cell	6. D-J rearranging.
f. Late pro-B cell	3. V-DJ rearranging