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MATHEMATICAL The kinetic data in the following table were obtained for the reaction of carbon dioxide and water to produce bicarbonate and hydrogen ion catalyzed by carbonic anhydrase:
[H. De Voe and G. B. Kistiakowsky, J. Am. Chem. Soc. 83, 274 (1961)]. From these data, determine
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Chapter 6 Solutions
Biochemistry
- MATHEMATICAL If a reaction can be written AB, and the G is 20kJmol1, what would the substrate/product ratio have to be for the reaction to be thermodynamically favorable?arrow_forwardREFLECT AND APPLY You are studying with a friend who is describing the Bohr effect. She tells you that in the lungs, hemoglobin binds oxygen and releases hydrogen ion; as a result, the pH in- creases. She goes on to say that in actively metabolizing muscle tissue, hemoglobin releases oxygen and binds hydrogen ion and, as a result, the pH decreases. Do you agree with her reasoning? Why or why not?arrow_forwardREFLECT AND APPLY Why is it advantageous for a cell to have organelles? Discuss this concept from the standpoint of thermodynamics.arrow_forward
- MATHEMATICAL Calculate the hydrogen ion concentration, [H+], for each of the following materials: (a) Saliva, pH 6.5 (b) Intracellular fluid of liver, pH 6.9 (c) Tomato juice, pH 4.3 (d) Grapefruit juice, pH 3.2arrow_forwardREFLECT AND APPLY What are some of the difficulties in determining the exact number of protons pumped across the inner mitochondrial membrane by the respiratory complexes?arrow_forwardMATHEMATICAL The standard free-energy change for the reaction Arginine+ATPPhosphoarginine+ADP is +1.7kJmol1. From this information and that in Table 15.1, calculate the G for the reaction Phosphoarginine+H2OArginine+Piarrow_forward
- REFLECT AND APPLY The following half reactions play important roles in metabolism. 1/2O2+2H++2eH2ONADH+H+NAD++2H++2e Which of these two is a half reaction of oxidation? Which one is a half reaction of reduction? Write the equation for the overall re- action. Which reagent is the oxidizing agent (electron acceptor)? Which reagent is the reducing agent (electron donor)?arrow_forwardREFLECT AND APPLY There is a reaction in carbohydrate meta- bolism in which glucose-6-phosphate reacts with NADP+ to give 6-phosphoglucono- -lactone and NADPH. In this reaction, which substance is oxidized, and which is reduced? Which substance is the oxidizing agent, and which is the reducing agent?arrow_forwardREFLECT AND APPLY In which of the following processes does the entropy increase? In each case, explain why it does or does not increase. (a) A bottle of ammonia is opened. The odor of ammonia is soon apparent throughout the room. (b) Sodium chloride dissolves in water. (c) A protein is completely hydrolyzed to the component amino acids. Hint: For Questions 37 through 39, consider the equation G=HT(S).arrow_forward
- MATHEMATICAL For an enzyme that displays MichaelisMenten kinetics, what is the reaction velocity, V (as a percentage of Vmax), observed at the following values? (a) [S]=KM (b) [S]=0.5KM (c) [S]=0.1KM (d) [S]=2KM (e) [S]=10KMarrow_forwardREFLECT AND APPLY Why is the development of catalysis important to the development of life?arrow_forwardMATHEMATICAL What is the [CH3COO]/[CH3COOH] ratio in an acetate buffer at pH 4.00?arrow_forward
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning