Biology (MindTap Course List)
Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 6, Problem 7TYU

When growth hormone binds to an enzyme-linked receptor, (a) G proteins are amplified into a cascade of molecules (b) the enzyme portion of the receptor becomes dephosphorylated (c) the receptor becomes activated and phosphorylates signaling proteins in the cell (d) an ion channel is opened (e) an immediate signal is sent into the nucleus, and specific genes are activated or inhibited

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One such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below Which of the proteins demonstrate the tightest/strongest binding of the hormone? Which demonstrates the least tight binding of the hormone? What is the basis for your answer?
Consider the structure of cholesterol, a small hydrophobic molecule with a sterol backbone similar to that of three of the hormones, but possessing fewer polar groups such as –OH, =O, and –COO–. If cholesterol were not normally found in cell membranes, could it be used effectively as a hormone if an appropriate intracellular receptor evolved?
Thyroid hormone receptor (TR) regulates growth, development, and differentiation of mammals. TR contains both a domain that binds to T3, the thyroid hormone, and a separate domain that binds to DNA. Which of the following BEST explains how TR signals?   A. T3 binds to TR at the cell membrane, which then releases second messengers to regulate gene expression.   B. T3 binds to DNA at the cell membrane, which then releases second messengers to regulate gene expression.   C. T3 diffuses through the cell membrane to bind to TR, which then binds to DNA to regulate gene expression.   D. T3 diffuses through the cell membrane to bind to DNA, which then binds to TR to regulate gene expression.
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