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Which of the following statements about inhibition is true? a. Allosteric inhibitors and allosteric activators are competitive for a given enzyme. b. If an inhibitor binds the active site, it is considered noncompetitive. c. If an inhibitor binds to a site other than the active site, this competitive inhibition. d. A noncompetitive inhibitor is believed to change the shape of the enzyme, making its active site inoperable. e. Competitive inhibition is usually not reversible.

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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
Publisher: Cengage Learning
ISBN: 9781305389892

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Chapter
Section
BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
Publisher: Cengage Learning
ISBN: 9781305389892
Chapter 6, Problem 9TYK
Textbook Problem
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Which of the following statements about inhibition is true?

a. Allosteric inhibitors and allosteric activators are competitive for a given enzyme.

b. If an inhibitor binds the active site, it is considered noncompetitive.

c. If an inhibitor binds to a site other than the active site, this competitive inhibition.

d. A noncompetitive inhibitor is believed to change the shape of the enzyme, making its active site inoperable.

e. Competitive inhibition is usually not reversible.

Summary Introduction

Introduction:

Enzymes are biological catalysts that increase the speed of metabolic reactions. Specific enzymes are involved in different biological reactions. Enzymes have an active site at which the substrate molecules bind. The binding of the substrate alters the shape of the enzyme and allows the substrate molecules to interact with each other, leading to the formation of specific products. The activity of enzymes can be inhibited to control various metabolic pathways. This inhibition can be of two main types, namely, competitive and non-competitive inhibition.

Explanation of Solution

Explanation for the correct answer:

Option (d) states that a noncompetitive inhibitor changes the shape of the enzyme that makes the active site inoperable. In noncompetitive inhibition, the inhibitor binds to a site of the enzyme which is different from the active site. This alters the shape of the enzyme and the substrate can no longer bind to the enzyme's active site, thus preventing the reaction from taking place. Hence, option (d) is correct.

Explanation for the incorrect answers:

Option (a) states that allosteric inhibitors as well as activators are competitive for a particular enzyme. The allosteric regulatory molecules (activators or inhibitors) bind to the enzyme at a site other than the active site. Their action is non-competitive in nature. The allosteric activator increases the enzyme affinity towards its substrate and promotes strong binding between enzymes and the substrates to facilitate faster reactions. On the other hand, allosteric inhibitors decrease the enzyme's affinity towards its substrate as they inactivate the enzymes. So, option (a) is incorrect.

Option (b) states that the binding of the inhibitor to the active site is called noncompetitive inhibition. This is incorrect as the binding of the inhibitor to the active site of the enzyme gives rise to competitive inhibition, during which the inhibitor competes with the substrate for the substrate-binding site of the enzyme...

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