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Mutations Can Uncouple chromosomal Sex from Phenotypic Sex Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (discuss Wolffian/Müllerian ducts and external genitalia), and (3) are sterile or fertile. a. XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone b. XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone c. XY, heterozygous for a recessive mutation in the MIH gene d. XY, homozygous fora recessive mutation in the SRY gene that abolishes function

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 7, Problem 12QP
Textbook Problem
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Mutations Can Uncouple chromosomal Sex from Phenotypic Sex

Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (discuss Wolffian/Müllerian ducts and external genitalia), and (3) are sterile or fertile.

  1. a. XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone
  2. b. XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone
  3. c. XY, heterozygous for a recessive mutation in the MIH gene
  4. d. XY, homozygous fora recessive mutation in the SRY gene that abolishes function

a.

Summary Introduction

To explain: Whether the following individuals represent female or male gonads, they are phenotypically female or male and they are fertile or sterile.

Introduction: The variations which occurs in the genetic material of the organisms from a source or randomly are called “mutations.” The minute changes in the DNA fragment new variations among the individuals which makes them different from each other.

Explanation of Solution

An individual which shows the absence of testosterone:

  • • The formation of testes takes place from the gonads when the SRY gene is active.
  • • There will no development of Wolffian duct in the absence of testosterone...

b.

Summary Introduction

To explain: Whether the following individuals represent female or male gonads, they are phenotypically female or male and they are fertile or sterile due to continuous production of testosterone.

Introduction: The variations which occurs in the genetic material of the organisms from a source or randomly are called “mutations.” The minute changes in the DNA fragment new variations among the individuals which makes them different from each other.

c.

Summary Introduction

To explain: Whether the following individuals represent female or male gonads, they are phenotypically female or male and they are fertile or sterile due to recessive mutation in MIH gene.

Introduction: The variations which occurs in the genetic material of the organisms from a source or randomly are called “mutations.” The minute changes in the DNA fragment caused the very new variations among the individuals which makes them different from each other.

d.

Summary Introduction

To explain: Whether the following individuals represent female or male gonads, they are phenotypically female or male and they are fertile or sterile due to inactive SRY gene.

Introduction: The variations which occurs in the genetic material of the organisms from a source or randomly are called “mutations.” The minute changes in the DNA fragment caused the very new variations among the individuals which makes them different from each other.

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