Study Guide and Solutions Manual for Essentials of Genetics
Study Guide and Solutions Manual for Essentials of Genetics
9th Edition
ISBN: 9780134189987
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Harry Nickla
Publisher: PEARSON
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Chapter 7, Problem 1CS

CASE STUDY | Links to autism

As parents of an autistic child, a couple decided that entering a research study would not only educate them about their son's condition, but also help further research into this complex, behaviorally defined disorder. In an interview, researchers explained to the parents that autism results from the action of hundreds of genes and that no single gene accounts for more than a small percentage of cases. Recent studies have identified 18 genes that have a higher likelihood of involvement, referred to as candidate genes; three of these, on chromosomes 2, 7, and 14, are regarded as very strong candidate genes. Generally unaware of the principles of basic genetics, the couple asked a number of interesting questions. If you were the interviewer, how would you respond to them?

How might identification of a “candidate” gene be helpful in treating autism?

Expert Solution & Answer
Check Mark
Summary Introduction

To analyze:

The query of the parents of an autistic child, about the risk of having second child autistic, as the genetic condition depends on several factors.

Introduction:

Autism is the disease that is a result of the action of hundreds of genes. Almost 18 genes are known to be most likely involved in it, that are referred to as “candidate” gene. Out of 18 genes, three genes are present on chromosome number 2, 7, and 14, which are regarded as a strong candidate gene.

Explanation of Solution

Autism is a neurodevelopmental disorder that affects the individual’s ability to interact with people. It occurs at very early stage in childhood. Autism has a genetic basis, even though the genetics of the autism is complex.

Selection of candidate gene can be helpful in treating the autism. The researchers can locate the gene and can isolate the mutation. The treatment regimens can be developed by the researchers to treat the mutation, by targeting those specific mutations. Gene knockout and gene knock-in can be used through either the mutated genes are deleted from the organism or in place of the defected gene new gene is inserted, for its normal function.

Neuroligin 3 is a cell adhesion protein that functions to connect the brain cells to each other. Mutation in the neuroligin 3, that leads to the change in 451 amino acid from arginine to cystine. It is the genetic change associated with autism. This change can be corrected by targeting the gene and so the identification of the gene can be helpful in treating the autism.

As this genetic disorder is controlled by a number of genes, researchers suggest that there is a higher probability of autism in second child also, as the siblings share similarity with respect to their genetic structure.

Conclusion

Therefore, it can be concluded that identification of the candidate gene can be helpful in treating the autism, and there is a higher probability of autism in second child if the first one is autistic.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Students have asked these similar questions
Please answer all questions if possible. 1. Why are genetic screens useful? Why do biologists do screens? What are we trying to do? What is the Big Picture purpose? 2. Why would a researcher be interested in over- or mis- expression phenotypes?
The role of the TPMT genotype in response to treatment emphasizes the importance of pharmacogenomics. What changes in treatment would be recommended for someone homozygous recessive for TPMT, compared to someone that is homozygous dominant?
Give a schematic diagram of how we can Treatment Down's syndrome  by using gene therapy? Please answer at your own words,please..

Chapter 7 Solutions

Study Guide and Solutions Manual for Essentials of Genetics

Knowledge Booster
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • 1. What role does a patient's genetics have in their symptoms of muscular dystrophy? What causes various mutations to cause distinct symptoms? (two to three sentences) (Think about why various mutations in different genes cause different illnesses.)2. What can family history teach you about a patient's muscular dystrophy inheritance and, hence, genetic basis? (two to three sentences)3. The X-chromosome contains the mutation that causes Duchenne Muscular Dystrophy (DMD). Explains how this impacts DMD inheritance and why DMD patients are disproportionately male. (two to three sentences)
    Many genetic counselors will not provide presymptomatic genetic testing for Huntington disease to people below the age of 18. Why are there concerns about offering this and many other genetic tests to minors? What types of presymptomatic genetic testing might be appropriate for minors?
    Fragile X syndrome why is interesting Fragile X syndrome  What are the symptoms or characteristics of this disorder or trait?  What is the prevalence of the trait or disorder? What are the main genetic factors? s the genetic cause of this disorder or trait known? What gene(s) have been proven to be involved? Or, if not known, what genes are thought to be involved? Is it caused by a single gene? polygenic? Multifactorial? Devote a few paragraphs to this   This could be one of the longest parts of the paper, if you choose to focus on this. If multiple genes are thought to be involved, discuss the specific role of at least one of them in depth  (if known). Is the gene you’re discussing thought to play a major or a minor role in the phenotype? What chromosome is it on? What protein does it code for, and how might the protein possibly contribute to the phenotype? If no genes have yet been identified, indicate this, and devote at least one paragraph to any current efforts to determine which…
  • The ability of humans to taste the bitter chemical phenylthiocarbamide (PTC) is a genetic trait. People with at least one copy of the normal, dominant allele of the PTC gene can taste PTC; those who are homozygous for a mutant, recessive allele cannot taste it. Could two parents able to taste PTC have a nontaster child? Could nontaster parents have a child able to taste PTC? A pair of taster parents, both of whom had one parent able to taste PTC and one nontaster parent, are expecting their first child. What is the chance that the child will be able to taste PTC? Unable to taste PTC? Suppose the first child is a nontaster. What is the chance that their second child will also be unable to taste PTC?
    1) Perception of a bitter taste from phenylthiocarbamide (PTC) is dominant (T) to not being able to taste PTC. Albinism is recessive to normal pigmentation (A). The genes controlling these traits are on separate chromosomes. a. A normally pigmented woman who cannot taste PTC has a father who is an albino taster, marries a many homozygous for normal pigmentation who is a PTC taster, but whose mother did not taste PTC. What are the genotypes of the woman and man listed here? b. Assuming the man and woman in the above section have children, what percentage of these children will be albino? c. What percentage of these children will have the same phenotype as their mother?
    How we can Treatment Parkinson's disease by using gene therapy? Please answer at your own words,please..
    • SEE MORE QUESTIONS
    Recommended textbooks for you
  • Biology Today and Tomorrow without Physiology (Mi...
    Biology
    ISBN:9781305117396
    Author:Cecie Starr, Christine Evers, Lisa Starr
    Publisher:Cengage Learning
    Biology: The Dynamic Science (MindTap Course List)
    Biology
    ISBN:9781305389892
    Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
    Publisher:Cengage Learning
    Biology (MindTap Course List)
    Biology
    ISBN:9781337392938
    Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
    Publisher:Cengage Learning
  • Biology: The Unity and Diversity of Life (MindTap...
    Biology
    ISBN:9781305073951
    Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
    Publisher:Cengage Learning
  • Biology Today and Tomorrow without Physiology (Mi...
    Biology
    ISBN:9781305117396
    Author:Cecie Starr, Christine Evers, Lisa Starr
    Publisher:Cengage Learning
    Biology: The Dynamic Science (MindTap Course List)
    Biology
    ISBN:9781305389892
    Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
    Publisher:Cengage Learning
    Biology (MindTap Course List)
    Biology
    ISBN:9781337392938
    Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
    Publisher:Cengage Learning
    Biology: The Unity and Diversity of Life (MindTap...
    Biology
    ISBN:9781305073951
    Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
    Publisher:Cengage Learning
    Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY