Concept explainers
To examine: Whether the statement “in terms of the way it interacts with DNA, the helix-loop-helix motif is more closely related to the leucine zipper motif than it is to the helix-turn-helix motif” is true or false.
Introduction:
A DNA-binding domain consists of a structural motif that recognizes a DNA sequence. The common motifs are helix-turn-helix, leucine zipper, helix-loop-helix, homeodomain, and zinc fingers.
Answer to Problem 1P
Correct answer: The statement is true.
Explanation of Solution
Helix-turn-helix motif is simple and constitutes two α helices connected by a short amino acid chain that forms the turn. Leucine zipper motif consists of two α helices joined together to constitute a short coil. They are bound together by interactions between hydrophobic side chains extending from a side of helix. Helix-loop-helix is similar to leucine zipper motif as it consists of a short α helix connected by a loop. The α helices in both leucine zipper proteins and helix-loop-helix proteins extend from the dimerization interface for the interaction with DNA. Thus, helix-loop-helix motif is more closely related to the leucine zipper motif.
Hence, the statement is true.
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Chapter 7 Solutions
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