Essential Cell Biology (fifth Edition)
Essential Cell Biology (fifth Edition)
5th Edition
ISBN: 9780393680362
Author: ALBERTS, Bruce, Hopkin, Karen, Johnson -
Publisher: W. W. Norton & Company
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Chapter 7, Problem 1Q
Summary Introduction

To evaluate: Whether the word ‘dogma’ is appropriate in reference to “central dogma” which means flow of genetic information from DNA to RNA to protein.

Introduction: The genetic information is used to form a functional product in the form of proteins and is known as gene expression. Information flows in direction from DNA to RNA (transcription) and then RNA to proteins (translation). This is referred as central dogma of molecular biology.

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Explanation of Solution

The term ‘dogma’ generally refers to the principles laid by an authority or a belief that cannot be doubted. The flow of genetic information from DNA to proteins is one of the fundamental principles in molecular biology. The ‘central dogma’ is essential as it gives a framework on how the genetic information flows to form a functional protein product in cells. It was proposed by Francis Crick in year 1958 and he himself explained why he coined this term (What Mad Pursuit: A Personal View of Scientific discovery, Basic Books, 1988). There was little direct experimental support at that time. He stated that he used the term ‘central dogma’ because it was based on the powerful assumption that genetic information is encoded by DNA nucleotide base sequences. So, the usage of dogma in reference to central dogma may be considered as appropriate.

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