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Cardiopulmonary Anatomy & Physiolo...

7th Edition
Des Jardins + 1 other
ISBN: 9781337794909

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BuyFindarrow_forward

Cardiopulmonary Anatomy & Physiolo...

7th Edition
Des Jardins + 1 other
ISBN: 9781337794909
Textbook Problem

Which of the following will readily diffuse across the blood-brain barrier?

1. CO 2

2. H +

3. HCO 3 -

4. H 2 CO 3

A. 1 only

B. 2 only

C. 3 only

D. 2 and 4 only

Summary Introduction

Introduction:

Blood-brain barrier is a semipermeable barrier that separates the circulating blood from the extracellular fluid and brain in the central nervous system. It is formed by the endothelial cells of the capillary wall. This barrier restricts the movement of some molecules while facilitating the movements of other molecules.

Explanation

Justification for the correct answer:

Option (A) is, ‘1 only.’ This option is correct, as the blood-brain barrier restricts the movement of solutes and other large hydrophilic molecules into the cerebrospinal fluid. It allows the diffusion of hydrophobic molecules, such as, carbon dioxide, oxygen, hormones, and other polar molecules. Hence, option (A) is the correct answer.

Justification for the incorrect answers:

Option (B) is, ‘2 only’. It is false, as the blood-brain barrier is impermeable to hydrogen ions as the cerebrospinal fluid has an inefficient buffering system...

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