Cystic Fibrosis Essay

college student and also a close friend of mine who has been battling Cystic Fibrosis since she was three years old. Cystic Fibrosis is a genetic condition that causes mucus to build up in the lungs and digestive system, making it hard to breath. “Basically everything in my body is thicker, so the mucus in my lungs is harder to break up and get out which causes frequent lung infections.” Amanda explained to me. Cystic Fibrosis also impacts her ability to digest food, resulting in her being underweight

Current: Orkambi® (ivacaftor and lumacaftor): Other Pulmonary i. Cystic Fibrosis (CF) affects those that are homozygous recessive for the F508del mutation in the CFTR (Cystic Fibrosis transmembrane conductance regulator) gene ii. 2004: Ivacaflor (VX-770), Brand name: Kalydeco, a CFTR (cystic fibrosis transmembrane conductor regulator) potentiator discovered at Vertex Pharmaceutical Incorporated iii. 2005: VX-770 clears the pre-clinical trials leading to IND submission. 3-13-2006: IND submitted for

Cystic fibrosis, a genetic disorder, is currently affecting more than 30,000 people in the United States (About). According to “What is a Genetic Disorder?” (2014) “A genetic disorder is a disease that is caused by a change, or mutation, in an individual’s DNA sequence.” Cystic Fibrosis is an uncommon but serious disorder that causes consistent lung infections and limits the ability to breathe overtime. It affects the exocrine glands, which play a crucial role in regulating body temperature by producing

The discovery of therapeutic molecules that target the underlying cause of Cystic Fibrosis, rather than the symptoms, has transformed the approach of cystic fibrosis treatments. Two such sets of drugs are classed as correctors and potentiators. The latter set aim to target and augment the function of the mutated CFTR channel that is present on the membrane. Class III and IV CFTR mutations benefit from this approach as they are defined as mutated CFTR channels that, although present on the apical

factor. Carlos is a carrier of Cystic Fibrosis and had a brother who had the disease. Carlos would like Mollie to get test for Cystic Fibrosis before having a child. Mollie is unsure about being tested but agreed to think about it. Cystic Fibrosis affects over 50,000 people in the United States, Canada and Europe (3). One in every twenty Americans are carriers of Cystic Fibrosis, approximately twelve million people are unaware they are carriers (3). Cystic Fibrosis is autosomal recessive inherited

numerous treatments each day to counteract the symptoms that accompany cystic fibrosis including physiotherapy, pills containing digestive enzymes, and a treatment which breaks up the mucus in her lungs. Cystic Fibrosis has numerous life threatening symptoms and while there is no cure, there are several treatments that a typical patient undergoes each day to combat these symptoms. The most prominent symptom associated with Cystic Fibrosis is a thick mucus that clogs up tubes that carry out crucial roles

Cystic Fibrosis is an inherited recessive gene which means the disorder won’t affect anyone that’s a carrier. To obtain Cystic Fibrosis there are two ways, either, one parent is a carrier and the other has it (provided the parent with Cystic Fibrosis is female), or both parents are carriers. Parents can find out if they are carriers for Cystic Fibrosis with the use of genetic testing. When both parents are carriers for Cystic Fibrosis there a 25% chance the child will have Cystic Fibrosis, a 50%

Brief History Cystic Fibrosis was first recognized in 1938, as an individual disease or distinct entity, which basically means that the symptoms were not related to any other illness (Davis, 2006), but there was a common passage in the ‘Almanac of Children’s Songs and Games from Switzerland’, the passage read, ‘the child will soon die who’s brow tastes salty when kissed’, which hinted at the saltiness of the skin of infants who died might relate to Cystic Fibrosis. Autopsies were done in 1838 on

Cystic Fibrosis is a genetic disease that causes multiple lung infections and limits the ability to breathe over the span of a lime time. Cystic Fibrosis causes a thick buildup of mucus in the lungs, pancreas, and other organs, so Cystic Fibrosis is not only a respiratory disease but can also cause problems in the digestive system. While the buildup of mucus on the lungs doesn’t allow the person to breathe as well, the buildup of mucus in the pancreas doesn’t allow the release of digestive enzymes

Cystic fibrosis is a scary disease. The life expectance for people with cystic fibrosis is in batween thirties and forties. It was discovered in 1938. There are more than 1,500 mutations that have identified in the single gene. The symptoms that infants or kids may have if they have cystic fibrosis is nasal polyps, prolonged jaundice, severe malnutrition, and meconium ileus (bowel obstruction). The symptoms that are found in infants, children and adults are production of bulky foul smelling stools