Acetic anhydride

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  • The Melting Point Analysis of Crude and Recrystallized Acetaminophen Synthesized from P-Aminophenol and Acetic Anhydride

    1092 Words  | 5 Pages

    Abstract Acetic Anhydride and p-Aminophenol were heated in a vial attached to an air condenser to synthesize crude acetaminophen, resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken, and found to be 165.9 - 170.9°C and 168.2 - 171.5°C, respectively. The literature melting point of acetaminophen

  • Preparation of Aspirin and Determination of the Melting Point

    1445 Words  | 6 Pages

    of Santo Tomas Manila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentage yield of the synthesis was calculated to be 78.42%. The experimental melting point range of aspirin was determined

  • Synthesis of Aspirin Lab Report

    2989 Words  | 12 Pages

    acid, was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in the

  • The Synthesis Of A Medicinal Agent Essay

    938 Words  | 4 Pages

    was synthesized from a reaction between salicylic acid and acetic anhydride. Acetic anhydride was added to salicylic acid to create a solution and phosphoric acid was added to catalyze the reaction. After the salicylic acid was fully dissolved in a boiling water bath, water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were collected and separated from the remaining acetic acid-water solution. Then, the product of the reaction would

  • Organic Chemistry Experiment 10 Formal Report

    1855 Words  | 8 Pages

    Carboxylic acid derivatives namely, acyl halides, acid anhydrides, esters and amides were classified through different reactivity tests. The samples used were acetyl chloride for acyl halide group, acetic anhydride for acid anhydride group, ethyl acetate for ester group,

  • Essay on Synthesis of Aspirin

    5275 Words  | 22 Pages

    purity of aspirin by adding Iron (III) chloride to the product. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid (aspirin) and acetic acid (vinegar). Variables: Independent and controlled variables: The amount of sulfuric acid used for catalysis and the amount of salicylic acid and acetic anhydride. Dependent variables: Theoretical and actual yield of

  • Characteristics Of Aspirin

    713 Words  | 3 Pages

    SYNTHESIS AND CHARACTERISTICS OF ASPIRIN- ACETYLSALCYLIC ACID Summary: The lab experiment was divided into parts and the synthesis of the aspirin occurred during the first week. Using 4.032g of salicylic acid 8.0mL of acetic anhydride on a hot bath the reaction was speeded up by the use of a catalyst phosphoric acid. Once the sample was then left to dry in the drawer for a week using the melting point apparatus we conducted the purity assessment of the dried sample. Introduction: Aspirin (acetylsalicylic

  • Result Analysis Of Aspirin

    957 Words  | 4 Pages

    excess acetic anhydride with the salicylic acid. During its synthesis a small quantity of a strong acid is used as a catalyst. Strong phosphoric acid was used as a catalyst in this experiment. The excess acetic acid was quenched by addition of water. Beer’s law shows the relationship

  • Synthesis Of Organic Compounds : Synthesis

    862 Words  | 4 Pages

    Laboratory 5: Synthesis of Organic Compounds Introduction: In this experiment, aspirin will be synthesized from salicylic acid using acetic anhydride. The sodium salt was initially prescribed for its antipyretic and analgesic effects, but the salt was too irritating to the stomach, so a phenyl ester version was developed as a replacement. The esterified version passed successfully through the acidic stomach without irritation. It was hydrolyzed in the basic environment of the intestines,

  • The Preparation of Acetaminophen (Paracetamol) with Thin Layer Chromatography (Tlc) to Monitor the Reaction.

    2092 Words  | 9 Pages

    Abstract: This experiment is to demonstrate the preparation of paracetamol and its properties. Reflux and filtration of 4-aminophenol and acetic anhydride formed the crude sample. Further analysis of dry white crystals were used to give quantitative measurements and a percentage yield of 46% was obtained. The overall conclusion is that the acetic anhydride reacted with the –NH2 group. Materials and Methods: 1. We weighed out (on a top-pan balance) 4-aminophenol (about 11.0g) in a weighing