Aldosterone

Aldosterone and Hormone Replacement Therapy Aldosterone falls in the class of hormone called mineralocorticoids, produces by the adrenal glands and is found near the kidneys. It sustains blood pressure, water and salt balance within the body. This procedure is assisting the kidneys to preserve sodium and excrete potassium in order to maintain a balance. If Aldosterone production falls, there isn’t enough regulation of salt and water balance (as aldosterone is being lost through urination) triggering

Mineracorticoid receptor antagonists (MRA) Reduced cardiac output in CHF patients via activation of renin angiotensin system may lead to circulating aldosterone levels that are nearly 20 times above normal. The pathophysiological effects of raised aldosterone levels in these patients are diverse and include sodium and water retention, increased loss of K+ and Mg2+, myocardial and vascular fibrosis, reduced uptake of norepinephrine in the myocardium, baroreceptor dysfunction and alterations in sodium

other ACE Inhibitors are Enalapril, Quinapril, Captopril and Lisinopril. The oral bioavailability of Tritace is 55%. The absorption is not significantly affected by food and the duration of action is 24 hours. 2.0 Physiology of Renin-Angiotensin-Aldosterone System (RAAS) Baroreceptors located in the aortic arch and carotid sinuses detect changes in blood pressure. When a drop in blood pressure is detected,

Explanation of coronary heart disease. Currently, cardiovascular disease is “the number one killer in the United States and the developed world” (Sapolsky, 2004, p. 41). Coronary heart disease (CHD) is the most common form of cardiovascular disease, which is killing more than 7 million individuals on an annual basis. Disorder, which underlines CHD, is called atherosclerosis, process that involves inflammation of the lining of blood vessels leading to progressive accumulation of macrophages, lipid

reactions. One endocrine gland that is incredibly important in the body is the adrenal gland, as it is essentially responsible for the 'fight or flight' response by secreting Epinephrine, Norepinephrine, and maintaining bodily homeostasis by secreting Aldosterone and Cortisol, although Cortisol also contributes to the stress response. However there is a lot of minuscule

1. What are the novel findings the manuscript “Angiotensin II- and Salt-Induced Kidney Injury”? The novel findings in the manuscript are: (a) Ang-2/salt induced kidney injury is by Rac1-mediated MR activation. (b) MR activation can be regulated by Rac1 through ligand independent mechanism. 2. What is the effect of low and high salt on blood pressure and kidney function in normal mice (C57)? In C57 mice there is no significant effect on the blood pressure and renal function in both high and low

There are two hormones in the body that contribute to the control of urine volume of composition: aldosterone and vasopressin. Vasopressin, also known as antidiuretic hormone, acts on principal cells to promote water reuptake back into the body. This results in concentrated urine because most of the water is reabsorbed back into the blood. Fluid deprived subjects stimulated more vasopressin in order to retain as much water as possible in order to prevent dehydration as much as possible. As the blood

The kidneys serve the primary functions of regulating plasma volume, electrolyte balance, producing hormones, acid and base balance, removing waste, and retaining water to produce urine. These wastes come from the breakdown products of metabolically active muscle, and from food consumed. Your body utilizes what it needs, and the waste is sent into the urine. The body will regulate water volume within the body by helping the body retain water when plasma osmolarity decreases, as well as excrete water

Addison’s disease is the outcome of a loss of cortisol and aldosterone secretion. This is a result of the obliteration of the adrenal glands. The most common cause of Addison’s disease was tuberculosis up until the mid twentieth century. Then, it was found that an autoimmune reaction that makes antibodies against the adrenal glands was also a major cause of this disease. Other less common causes like fungal infections, a virus associated with AIDS, and cancer cells were also found. Someone with

Aldosterone antagonists is recommended in selected patients with moderately severe to severe symptoms with careful monitoring of renal function and potassium concentration. Creatinine level should be less than 2.5 mg/dl and potassium should be less than 5.0