Anticonvulsant

Pharmacology The preliminary evaluation of the titled compounds 7a-7o and 8a-8e were evaluated for anticonvulsant activity utilizing the predictable animal models and the neurotoxicity was assessed by rotorod test method. Of these, the MES and scPTZ seizure models represent the two animal seizure models, most widely used in the search for new anticonvulsants. Data are presented (Table II) after the 0.5 and 4 h time intervals at the dose level of 30, 100 and 300 mg/kg. Phenytoin and carbamazepine

Introduction Bipolar Disorder, also known as manic depression in layman's terms, is basically a psychiatric condition in which an individual suffers extreme mood swings, ranging from a highly elevated mood (Johnson, 2005) to low levels of depression (Motovsky & Pecenak, 2013). These shifts in mood result in changes in behavior and thinking of the affected individuals. However, the condition only affects the person mentally. Bipolar disorders in patients are hard to identify initially as they can

affects 1-2% of the population. Genetics plays a significant role. About 15% of children with one bipolar parent develop the disorder. Treatments include medication, supportive psychotherapy and occasionally ECT. Medications include lithium, anticonvulsant drugs (carbamazepine (Tegretol), valproate (Depakote), gabapentin (Neurontin) and lamotrigine Lamictal), antidepressants (such as bupropion (Wellbutrin)or sertraline (Zoloft)), neuroleptics (e.g. haloperidol) and benzodiazepines (e.g. lorazepam)

Benzodiazepines include anticonvulsant drugs (tested in the study) and antidepression and anxiety drugs (medications my patient was on- specifically Xanax)- However to perfectly match the study to the clinical problem, Cerebral Palsy patients taking Xanax could be measured against Cerebral Palsy patient not taking any medication plus a control group of normal individuals. The definitions used in the study were similar to the PICO research term. The health care system in the study was in Brazil

p. 370). Lithium was the first effective anticonvulsant that has had success in the treatment of bipolar manic symptoms. The mechanisms in which Lithium works are unknown along with the neurological dysfunction that triggers the development and manifestation of bipolar disorder (Stahl, 2013. p. 371)

endogenous female sex hormones (Sharma and Bhatnagar, 2011). Moreover, the ethno medical use of A. racemosus root as an anticonvulsant has been experimentally validated in our laboratory (unpublished data) as well as by other researchers too (references). The available literature reveals that the plant has not been explored with respect to its therapeutic potential as an anticonvulsant in catamenial epilepsy. But nowadays the virtual screening of the phytochemicals is believed to be a major tool for

Pharmacological & Surgical Treatment of Trigeminal Neuralgia Trigeminal Neuralgia (TN) is painful facial syndrome that can be treated through various drugs and surgical procedures. The syndrome has been defined by the International Association for the Study of Pain (IASP) as “sudden, usually unilateral, severe, brief, stabbing, recurrent pains in the distribution of one of more branches of the fifth cranial nerve” . The two primary disease types that have been observed clinically are: idiopathic

Phenobarbital (PB) is a barbiturate that is used as an anticonvulsant drug that is commonly used to treat epilepsy. It is a cytochrome P450 enzyme inducer. Patients who not only use anticonvulsants, such as PB, but also overdose on paracetamol are more susceptible of developing liver damage. Phenobarbital will increase the hepatotoxic effects of paracetamol since it increases its rate of metabolism (Duggett, 2016). The detoxification pathway involving glutathione reserves are saturated and unable

treated at all (centre, 2015). Depending on the age of the patient, the patient is nearly two to four times more at risk for early death during a seizure episode. The primary treatment for epilepsy is phenobarbital which is the least expensive anticonvulsant used to control generalized and partial seizures. Unfortunately due to its abuse potential it is often a controlled substance in countries and therefore not recommended as a first line of treatment. The lack of the ability to treat the majority

The term “epilepsy” is derived from Greek word “epilambanein”, which means “to seize upon” or “to attack”. In this modern world, epilepsy is one of the most frequent neurodegenerative diseases. Epilepsy is a condition in which a person has recurrent seizures. Seizure can defined as an abnormal, disorderly discharging of nerve cells of brain; resulting in a temporary disturbance of motor, sensory, or mental function. Epilepsy is the most common neurological condition affecting people of all ages