Aptamer

drugs. Inhibition of FIX, FXI, and FXII has shown promising results of decreased thromboembolic events but are associated with bleeding. The role of FIX, FXI, and FXII inhibitors, antibodies, antisense oligonucleotides, active site blockers, and aptamers has been discussed. Although, these agents have a thromboprotective effect; however, as discussed, there are pros and cons of these agents and there is a lack of clinical trials involving human subjects. Thus, future in-depth studies involving large

3.3.8. Simplified Workflow for Nucleic Acid Isolation from Captured Cells An important aspect for cell capture devices is the ability to easily access cells and nucleic acids for downstream analysis (e.g. clonal expansion, fluorescence in situ hybridization (FISH), gene expression, and sequencing) to determine the type of primary tumor and monitor disease progression [130, 131]. Microfluidic cell capture approaches are typically formed by permanently bonding the channel network to the capture surface

Apple Scar Skin Viroid (ASSVd), a non-protein coding, single-stranded, circular RNA pathogen limits the detection based on the immunoassay. In this study, a visible nanobarcoding assay for one-step Reveres transcription loop-mediated isothermal amplification (RT-LAMP) was developed to improve the LAMP selectivity and promote its diagnostic use in detecting ASSVd in plants. ASSVd LAMP was accelerated by the use of loop primers and highly sensitive with a detection limit of 103 copies of ASSVd cDNA

Expression of the long non-coding RNA Sox2ot during postnatal developmental of the rat brain Introduction Long non-coding RNAs (lncRNAs) make up a large portion of cellular transcripts in the mammalian transcriptome (Clark and Blackshaw 2014) . In all human transcripts, at least 10,000 non-coding RNAs are thought to be greater than 200 base pairs (bps) in length, with little to no coding capacity, and are therefore classed as lncRNAs (Zhu et al. 2013; Clark and Blackshaw 2014). In some cases, transcripts

Tomato production is affected by various bacterial, fungal and viral diseases which resulted in considerable yield losses. Among those diseases, damping off, early blight, late blight, powdery mildew, bacterial leaf spot, bacterial canker, buck eye rot, fusarium wilt, tomato spotted wilt, tomato big bud, tomato bunch top , tomato mosaic and tomato leaf curl affect tomato production. Among all the diseases of tomato, leaf curl disease of tomato (ToLCD) is the most devastating one as its incidence

BioMEMS devices are manufactured using similar microfabrication techniques as those used in semiconductor processing (such as photolithography, thin-film deposition and etching ) to produce the desired configuration of features, including traces (thin metal wires), vias (interlayer connections), reservoirs, valves, and membranes. The interest in BioMEMS is growing rapidly, with opportunities in areas such as biosensors, pacemakers, immunoisolation capsules, and drug delivery [31]. Microcantilever

Research Writing Across the Discipline I. Targets and Objectives The learners are expected to: a. determine the purpose of research writing across discipline; b. discuss the process of making a research writing; c. distinguish the fields of research writing across discipline; and d. know the concept and principles of research writing across discipline; II. Topic and Subject Matter A. definition of research writing B. purpose of research writing across discipline

In 1956, Francis Crick first described what he called “The central dogma of molecular biology.” This essentially describes the flow of genetic information within cells. It states that DNA is transcribed into RNA with the help of an RNA polymerase enzyme. The RNA is then translated into a protein by protein synthesis. One thing that could drastically alter the genetic information within cells is a process called gene silencing. This process regulates the gene expression of certain genes and can

The Expression, Regulation and Function of Superantigens of Streptococcus and Staphylococcus A Review By Matt Ellison Word Count: 2114 1 Abstract Staphylococcus aureus and Group A streptococcus are the two very common bacteria to cause infections in humans which range from asymptomatic to extremely serious and even fatal. Some of the most powerful tools they have against the mammalian immune system are an array of exotoxins which are secreted proteins. Among these, the most powerful are the Superantigens

Nanomedicine, the application of nanotechnology in medicine has attracted a great deal of attention in the field of drug delivery and tissue engineering over the past few decades. This increasing interest in nanomedicine is driven by its potential to revolutionize the treatment of some prevalent global disease such as cancer, cardiovascular disorders, rheumatoid arthritis, osteoarthritis, and diabetes in safer and more effective ways [1, 2]. Nanotechnology refers to the engineering of materials at