Aspirin

Abstract This report presents the synthesis of Aspirin (acetylsalicylic acid), as the product of the reaction of salicylic acid with ethanoic anhydride under acidic conditions. Aspirin was purified through recrystallisation by vacuum filtration, followed by desiccation of the Aspirin crystal over silica gel. The percentage yield was calculated as 44.89% and a sample of Aspirin was analysed using infra-red spectroscopy and compared to the spectrum of pure Aspirin, this served as an introduction to the identification

The hydrolysis of aspirin in the absence and presence of rabbit serum Results In both saline and rabbit serum solutions, as the aspirin concentration increased, the salicylic acid concentration also increased. However, the salicylic acid concentration achieved in the saline solution at increasing concentrations of aspirin was not equivalent to the increase attained in the rabbit serum. In serum solution, the amount of salicylic acid metabolized from aspirin was always at least double that achieved

Objective: Students will be able to synthesize aspirin using an esterification reaction and conduct a purity test on the aspirin crystals and a commercial aspirin product. Procedure: Preparation of Aspirin- Begin by weighing a 125-mL Erlenmeyer flask and recording the result. Next, add approximately 2 g of salicylic acid to the Erlenmeyer flask. Then, record the new mass of the Erlenmeyer and the salicylic acid. Next, inside of the hood add 5 mL of acetic anhydride and 10 drops of 85% phosphoric

acid(aspirin) using different experimental techniques. These include recrystallization (purification), vacuum filtration (isolation), and melting point determination (characterization). After the melting point and a fair ferric chloride test was performed to test for the purity of the aspirin. The overall result was that the aspirin was light purple and the other vile dark purple. This showed that it was slightly impure. Introduction: In this lab I had found out the process of making aspirin through

EXPERIMENT 2- ANALYSIS OF ASPIRIN MATTHEW SKILTON DUE MONDAY FEBRUARY 13TH 2012 TA- ANA GARGAUN ABSTRACT In this experiment the concentration of acetyl salicylic acid (ASA) in an aspirin tablet will be determined. This can be done by dissolving a tablet in a strong base, NaOH, and titration it with a strong acid, HCl. The quantity was found to be about 75.5% of the weight of the tablet, or about 318 mg per tablet. This value tells the pharmaceutical companies how much to state the recommended

Aspirin Synthesis Organic chemical synthesis is the process of creating a different substance from two or more existing substances. It can be done naturally or through man made techniques. Synthesis has been going on for ages, although there was a time that we did not actually know that was what we were doing. The first conscious synthesis was when urea was made in 1828. Since then, this science has continued to become more developed and since World War II it has been growing exponentially. A complete

PREPARATION OF ASPIRIN AND DETERMINATION OF THE MELTING POINT Ferrer, Lara Melissa V. Faculty of Engineering University of Santo Tomas Manila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentage

Historical Developments Relevant to Aspirin: A historical Development that relates to Aspirin is the father of our modern Medicine Hippocrates, who was a Greek Physician, left records of how they treated headaches, fevers and pains, and to ease child- bearing pains with a powder made of the leaves and bark form a Willow Tree. Also the Ancient Egyptians left a medical text called “Ebers Papyrus” which is also lists willow among a list a plant and animal remedies for pain relief, fever reduction, and

The production and manufacture of Aspirin Aspirin is one of the most consumed painkillers created up to this date due to its reliability and low expense. It is often used to relieve minor aches and pains, reduce fever and as an anti-inflammatory medication. Due to its wide range of uses, the demand for this pharmaceutical is very high. As a result, manufacturers who produce this drug must be efficient in order to reduce the time taken to produce this drug and produce the in very high quantities

Experiment 19: Synthesis of Aspirin and Oil of Wintergreen The purpose of the lab was to synthesize aspirin and oil of wintergreen, and to determine its purity using recrystallization process, determining its melting point and using back-titration. To synthesize aspirin, salicylic acid and anhydride was used to drive the reaction to completion. In the synthesis of oil of wintergreen we reacted salicylic acid and methanol to produce methyl salicylate. This reaction is an example of a condensation