Azide alkyne Huisgen cycloaddition

the introduction of “Click chemistry”, demonstrate the role it plays in chemical biology filed, the typical synthesis way of this concept, and current application in drug synthesis and research. Keywords: Click chemistry, vivo system, Huisgen 1,3-dipolar cycloaddition, CuAAC, Diels-Alder reaction Introduction: The phrase "click chemistry" was invented by K. Barry Sharpless in 1998, and was first integrally described by Sharpless, Hartmuth Kolb, and M.G. Finn of The Scripps Research Institute in 2001