Carbon-13 NMR

strength of the magnetic field and the magnetic properties of the isotope of the atoms. NMR allows the observation of specific quantum mechanical magnetic properties of the atomic nucleus. Many scientific techniques exploit NMR phenomena to study molecular physics, crystals and non-crystalline materials [197]. It is also routinely used in advanced medical imaging techniques, such as in MRI. The principle of NMR usually involves two sequential

literature though Melting point, TLC, IR, 1H and 13C NMR Abstract: The synthesis of the product: β-D-glucose pentaacetate is done though the acetylation using acetic anhydride with D-glucose with the help of sodium acetate. The recrystallization of the product is done though a polar solvent like water. The Result of this experiment has a percentage yield of 61% and analytical methods that are to detect the products are 1H NMR, 13 C NMR, COSY, FTIR (IR), Thin Layer Chromatography (TLC) and

The biaryl scaffold has received increased attention as a privileged structure by the Pharmaceutical industry.16 Over the last two decades, methods for preparing biaryls have relied predominantly on cross-coupling. The power of this method was recognized and won a Nobel Prize in Chemistry in the 2010, one of the biaryl compounds-biphenyl is shown in (Figure 8). Figure 8. Structure of Biaryl 1.5 Tellurium

3-c]pyridine-3,6(7H)-dicarboxylate (4) Colorless crystals from methanol (0.61 g, 69 %). M.p. 197-198 oC. 1H NMR (400 MHz, DMSO, ppm): δ 1.16 (t, 6H, J¬ = 7.1 Hz, 2COOCH¬2¬CH¬3), 1.32 (t, 3H, J ¬= 7.1 Hz, COOCH¬2¬CH¬3), 2.79 (t, 2H, J¬ = 5.6 Hz, H-4), 3.61 ( t, 2H, J = 5.1 Hz, H-5), 4.16 (q, 4H, J¬ = 7.0 Hz, 2COOCH¬2¬CH¬3), 4.30 (q, 2H, J¬ = 7.0 Hz, COOCH¬2¬CH¬3), 4.48 (s, 2H, H-7).

compounds. The unknown compounds, Acid 2 and Alcohol D, were identified by using the knowledge of the reaction that took place, and the identity of the product that was synthesized. The identification of the product resulted from analysis of IR and NMR spectra. For this experiment, Alcohol D and Acid 2 reacted in the presence of concentrated sulfuric acid, resulting in a colorless solution with brown layer on top. After washes with sodium bicarbonate and brine, the pale-yellow liquid product was dried

The chirality of drugs has become important to understand in the field of medicine and pharmacology today. Asymmetric approaches have been under investigation to synthesize chiral centers or separate enantiomers of chiral molecules using chemical catalysts or enantioselective enzymes. With this is in mind, the experiment performed in lab today exhibits the use of an enzyme catalyzed reduction to fashion a chiral center. In this experiment, the enzymatic asymmetric reduction of 1-phenyl-1,2-propanedione

Introduction Nuclear magnetic resonance (NMR) spectroscopy and imaging are very useful tools that have practical applications for several different fields. Chemists can use NMR spectroscopy to determine the structure and composition of organic molecules. NMR imaging is used in the field of medicine to view detailed cross-sectional slices of the human body. NMR is used by the petroleum industry as well as the pharmaceutical industry. This report examines how NMR spectroscopy is used to determine the

3-diene and a dienophile. In this reaction, furan, the diene, reacted with maleic anhydride, the dienophile, to form exo-7-oxabicyclo[2.2.1]hept-anhydride, the adduct. The adduct was recovered via vacuum filtration, and the melting point, 1H-NMR and 12C-NMR Spectroscopy was obtained. This Diels-Alder Reaction yielded an exo adduct as opposed to an endo product. In more detail, the Diels-Alder reaction is the reaction in which the dienophile adds to the alkenes on the diene. The reaction forms a new

(0.9273 g) which gave an 11.31% yield. The ¹H NMR spectrum of the cyclohexene product (see Appendix A) displayed two resonance signals at (in ppm): δ = 7.04 (s, 4H), 3.75 (s, 4H), 3.02 (s, 2H). Table 1. Data collected from 1H NMR of dehydrated cyclohexene Product: Cyclohexene Theoretical Yield (mmol) 100 Actual Yield (mmol) 11.28 Percent Yield (%) 11.28 % 1H NMR Spectroscopy Proton(s) δ (ppm) A 5.67 B 1.96 C 1.67 A brief analysis of the 1H NMR spectrum indicated

derivatives has been described using 4-(1,3-dioxolan-2-yl)quinoline and different phenacyl bromides in acetone and followed by reacting with different acetylenes in DMF/K2CO3. The structure of the newly synthesized compounds was determined by IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. The in vitro antioxidant activity revealed that, among all the tested compounds 5n has exhibited maximum scavenging activity with ABTS. The compound 5b has showed good antiproliferative activity as good