Abstract: Sickle cell disease is a severe genetic disorder which generates deformed red blood cells (RBCs). These altered red blood cells can obstruct the blood vessels causing vaso-occlusion complications. The current management of sickle cell disease is symptomatic, with the lack of any specific treatment for vaso-occlusion. Some of the recent studies have suggested the role of pro-inflammatory activity of aged neutrophils and induction of neutrophil extracellular trap (NET) formation. In addition
Sickle Cell is a disease that you hear about, but not as often as you should. It is an inherited disease, “the name derives from the red cells in the blood of sufferers and they take on the shape on a sickle (crescent shape).” Another name for sickle cell is sickle cell anemia, because in some cases people become anemic. With this disease comes low levels of hemoglobin, which is the red substance in your blood that contains iron and carries oxygen. Due to the irregular shaped cells this can cause
Sickle cell disease is a genetic disease that caused by abnormalities in the production of hemoglobin of red blood cells, characterized by its sickle-like shape. While the main function of hemoglobin in red blood cells is to carry oxygen to different parts of the body, these sickle cells are unable to perform this task adequately. The sickle shape of these red blood cells contributes to lower blood flow through vessels as they begin to build up and block passage through smaller blood vessels (“Facts
in progress. Paper Drazen, C. H., Abel, R., Gabir, M., Farmer, G. and King, A. A., Prevalence of Developmental Delay and Contributing Factors Among Children With Sickle Cell Disease. 2016 Mar;63(3):504-10. doi: 10.1002/pbc.25838. Epub 2015 Nov 17 Presentation “The Assessment of Quality of Life in Infants with Sickle Cell Disease.” Mohamed Gabir. 2015 PHASE and SPRINGH Symposia; St. Louis, Missouri: July 30-31, 2015. 2. What can you do this year, including the upcoming summer, to strengthen
Sickle cell disease is an ailment that specifically targets red blood cells, causing them to sickle into a cone shape and hinders the transfer of oxygen to other parts of the body. Lack of oxygen can damage tissues and cause major problems for the person affected. As a black male, I am very familiar with sickle cell disease. I have family members with the disease, such as my uncle who was very susceptible to illness as a child due to the disease. I remember him telling me how his body would ache
Sickle cell disease is a hereditary blood disorder most common in the African American community. Many people are carriers of the sickle cell trait, however in order for a person to develop sickle cell disease both parents must have passed on the trait to their child. Sickle cell disease causes a mutation in normal red blood cells resulting in decreased tissue perfusion and organ damage. This causes partial or complete replacement of normal hemoglobin with abnormal shaped sickled cells. An abnormal
Sickle cell disease (SCD) is an inherited and noncontagious, lifelong condition. More specifically, per Ohaeri, Shokunbi, Akinlade, & Dare, 1995, SCD is a generic term for a group of genetic disorders characterized by the predominance of sickle cell hemoglobin (Hgb). Hemoglobin is a protein in the red blood cells that carries oxygen throughout the body. The disease produces significantly abnormal Hgb molecules in red blood cells (RBCs). In sickle cell anemia, the red blood cells become rigid and
Sickle Cell Disease (SCD) is an inherited autosomal recessive condition that causes the red blood cells (RBCs) to be crescent shaped. Sickle cell disease occurs in 1 out of every 400 African Americans births (Field, et al 2009). And according to the Centers of Disease Prevention and Control (CDC), 1 out of 13 African American babies are born with the sickle cell trait (SCT). At the same time SCD is present in only 1 out of 300 Caucasian babies, thus it is considered to be one of the most prevalent
Sickle-Cell Disease A group of disorders that have an impact on hemoglobin is called sickle-cell disease. This disease can be deadly and needs to be discussed. During the lecture about chapter five, the class learned about the sickle-cell disease. This paper will discuss what sickle-cell disease is, the different types, how common it is, who gets it, symptoms, lethal or manageable information, treatments, and diagnosis. Sickle-cell disease refers to an inherited blood disorder. One amino acid takes
Sickle Cell Disease (SCD) sickle shaped red blood cells are abnormal in size and function; compared to the Thalassemias red blood cells appear normal in appearance but there are not enough of them being produced for the body to sustain homeostasis. The two diseases have basic similarities within their diagnosis and treatments. They differ in the way of which, SCD complications exceed Thalassemias, with Thalassemias epidemiology reaching more ethnic backgrounds and numbers affected over a greater