Chirality

classified with a property called chirality. Chiral compounds are not superimposable meaning that the mirror image of a compound can not be rotated/flipped onto the original compound. There are some rules to identify if a compound is chiral or achiral. There are “chiral centers” within these chiral compounds and they can be either R or S, there are also some rules which are the “Cahn-Ingold-Prelog rules” that determine the molecules handedness (if they are R or S). Chirality is a property of individual

Stereochemistry Post Lab Report Reference: Experimental Organic Chemistry: A Miniscale and Microscale Approach, 6th ed., by Gilbert and Martin, Chapter 7 Discussion: The main purpose of this experiment was to study the mechanism of the isomerization of dimethyl maleate to dimethyl fumarate as well as to explore the different properties of enantiomers using (R) and (S) Carvone oils, such as polarimetry and odor. A percent yield was calculated based upon the original amount of dimethyl maleate added

In the first reaction of this experiment, 1-phenylethanol was reacted with vinyl acetate, using the acylase I enzyme. The enzyme’s chirality results in a preferred reaction with one alcohol enantiomer over the other. In the second reaction, the unreacted alcohol is reacted with (R)-(-)-acetoxyphenylacetic acid to create a diastereomer. By comparing the 1H-NMR spectra of the final product

The chirality of drugs has become important to understand in the field of medicine and pharmacology today. Asymmetric approaches have been under investigation to synthesize chiral centers or separate enantiomers of chiral molecules using chemical catalysts or enantioselective enzymes. With this is in mind, the experiment performed in lab today exhibits the use of an enzyme catalyzed reduction to fashion a chiral center. In this experiment, the enzymatic asymmetric reduction of 1-phenyl-1,2-propanedione

7) Discussion: In the stereochemistry lab, properties of enantiomers and diastereomers were analyzed. Enantiomer are non-superimposable, mirror images of each other and tend to have very similar chemical behavior. For this experiment, the R and S conformation of carvone was used. The different enantiomers were tested for odor and light rotation. For the odor, each enantiomer of carvones were analyzed by wafting and noting the smell. Although they should have different odors, they may smell the same

Interestingly, studies from our laboratory and others have demonstrated a stereochemical dependence for dSp processing by enzymes in ODNs. The first instance of a dSp diastereomer difference was reported from our laboratory when Klenow Fragment (exo-) was allowed to insert dATP opposite the isomers for which dSp1-containing ODNs were found to be the more favorable substrate for insertion and bypass.32 This study was extended to in vivo experiments by Neeley, et al. to include pol II and pol IV

Name: Chen Yao Le Lab Group: Tues Email: A0111185@nus.edu.sg Matriculation Number: A0111185R Date of Experiment: 17 February 2015 Experiment 6: Synthesis, Electronic Spectra, Structural Isomerism: Octahedral Co(III) complexes with Chloride and Ethylenediamine Ligands Abstract: In this experiment, Δ/Λ-[Co(en)3]Cl3∙4H2O was synthesized and the absorbance in UV-vis spectrum was recorded

Stereochemistry is fundamentally concerned with two types of isomers: Enantiomers and Diastereomers. Enantiomers are non-superimposable mirror images of each other, much like human right and left hands; they share many properties like melting and boiling points and are essentially identical, except for a few special areas such as smell. Diastereomers are any other compounds that are non-superimposable mirror images of one another yet share the same chemical formula. These isomers have significantly

Measuring Chirality in Ibuprofen Using a Homemade Polarimeter Sydney Guerin December 9, 2016 May River High School  Abstract For this project, I will be conducting multiple experiments regarding the chirality of different forms of ibuprofen. The question I’m trying to solve is whether or not common brands of ibuprofen have the same formulation. In order to perform this exercise, I will need to create a homemade polarimeter in order to measure the angle at which the brands of ibuprofen will reflect

by Sam Keane, the focus is placed on the interaction between elements and the human body. The reader is taken on a journey through the medical history of various metals, and their beneficial factors. The trip continues to the interesting topic of chirality, or “handedness” of different proteins. On the flipside, the deadly aspects of different elements, as well as their deceptive ways are discussed. These two chapters really grabbed my attention, as medical history has always been of interest to me