Congenital insensitivity to pain with anhidrosis

Introduction Congenital Insensitivity to Anhidrosis (or CIPA) is a rare genetic disease with the characteristics of not being able to feel any pain or temperature, and little or no sweating. It is inherited by an autosomal recessive pattern, meaning that both parents have a mutated NTRK1 gene, but they do not show any symptoms of CIPA. The damaged NTRK1gene produces proteins that cannot transmit signals. Since the neurons do not get any signals from the proteins, they perform apoptosis. Apoptosis

Congenital insensitivity to pain with anhidrosis (CIPA), also called hereditary sensory and autonomic neuropathy type IV, is an inherited disease that prevents the feeling of pain and decreased or absent sweating. This is an extremely rare autosomal recessive disease and is often fatal. CIPA is so dangerous because of how it affects and damages the functions of the nervous system. The nervous system is in many ways the most vital system of the body. It is responsible for monitoring and regulating

Cognitive Insensitivity to pain and anhidrosis (CIPA) is best described by the International Journal of Clinical Pediatric Dentistry (2015) as a disorder that occurs in the autonomic nervous system that is categorized as a level IV Hereditary Sensory and Autonomic Neuropathies (HSAN). 1846 marked the beginning of the recognition of HSAN, but it was not widely analyzed. Advancements in the research of the disorder did not occur largely until 1932 and then were sparse until 1963. Some of the first

Israel Aguilar Professor Jesu Biology 281 September 13, 2013 Congenital Insensitivity to Pain Congenital insensitivity to pain, also known as CIP, is a condition where an individual has somatosensory deficiency such as feeling ranges of heat, pain, or pressure. CIP was first discovered in 1953 by a man named Dearborn who was first diagnosed with the disease and was first labeled as Congenital Pure Analgesia. Studies have been done on multiple patients with CIP and scientists have discovered that

including children. When it affects children, it is referred to as juvenile ankylosing spondylitis. The most common age of onset of symptoms is in the second and third decades of life.” The most common symptoms of ankylosing spondylitis include: • Hip pain • Stiffness and limited motion in the lower

Congenital Insensitivity to Pain with Anhidrosis Congenital Insensitivity to Pain is a very amazing disease. I chose to report on the specific section of it dealing with Anhidrosis because this also leaves the infected individual with the inability to sweat. This causes problems such as fevers and overheating from over exertion or external heat which in turn can cause brain damage. Many people affected by this disease die before the age of twenty-five from infections left untreated, metal retardation

Abstract Congenital Insensitivity to Pain Other known as CIP has an unexplained reason as to why it happens to some but not others. Some symptoms of are recurring fevers, ability to sweat, No reaction to painful scenarios,and self mental retardation. The genetic basis for CIP is unknown as of right now. It is apart of the family disorder called HSAN which stand for hereditary sensory and autonomic neuropathy. Most people that have a disorder involving HSAN have some form of lose between pain and temperature

Congenital insensitivity to pain with anhidrosis is a hereditary gene that comes from a mutation in the NTRK1 gene. The NTRK1 gene provides instructions for making a receptor protein that binds to another protein called NGFB. NTRK1 is important for the survival of the nerve cells. It is found on the surface of cells, mostly neurons that transmit pain, temperature, and touch. The mutations mean it can’t transmit signals to the neurons then they die by self destruction, it is called apoptosis.

solution to the pain that they can't feel. Well most cases have a form of inherent between the family. Considering that most forms of Congenital Insensitivity To Pain is perceived that is shows no Physical Pain is show. the two common kind of CIP is with and without anhidrosis. As if you are to hit someone on the back of the head and they don't have a reaction due to the mutations in the SCN9A. Now lets Go into more depth about each topic that has to do with CIP for short. Having no pain mean nothing

unique genetic disease is Congenital Insensitivity to Pain with Anhidrosis or CIPA for short. This particular genetic disease causes people who have to it to not be able to feel pain or even differentiated between hot or cold. As well as be unable to sweat, because of the anhidrosis. This genetic condition is also known as hereditary sensory and autonomic neuropathy type IV, but in this paper it will only be referred to as CIPA. Congenital insensitivity to pain with anhidrosis, CIPA, is an inherited