DNA-binding domain

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    FUBP1

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    FUBP1, also known as Far Upstream Element Binding Protein 1, is a tumor suppressor gene located on the reverse strand of chromosome 1. The exact location of this gene is chr1:78,413,591-78,444,777. FUBP1 is a protein-encoded gene. This protein functions as an ATP-dependent DNA helicase. It regulates MYC expression by binding to a single-stranded far-upstream element upstream of the MYC promoter. It binds to multiple DNA elements. It may act as both an activator and repressor of transcription. [1]

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    experiments to identify protein binding partners. Using this approach we identified structure specific recognition protein 1 (SSRP1) and suppressor of Ty 16 (Spt16), the components of the heterodimeric FACT (facilitates chromatin transcription) complex (Orphanides et al., 1999), as the top protein hits that specifically bound to ALV but not HIV-1 IN. The FACT complex is a highly conserved general histone chaperone protein that is essential for transcription and DNA replication (Abe et al., 2011; Belotserkovskaya

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    5 and 10 and their association with the disease. “Chromosome 5 is estimated to contain 900 genes making up nearly 6% of all the DNA in the human body.” Several different variations of genes on chromosome 5 have been linked back to other inflammatory bowel diseases (Genetics Home Reference). “Chromosome 10 contains roughly 700-800 genes and makes up about 4.5% of every DNA in the human body.” Researchers don’t have much information on chromosome 10, more specifically the section in which gene 10q21

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    it leads to severe segmentation mutations (Nambu, 1996). When D was immunostained with mAb BP102, embryos showed central nervous system mutations resulting in deletion of ganglia, narrowing axons, and completely fused anterior and posterior axons. DNA analyses have concluded that the D gene encodes a protein gene that is made up of 382 amino acids. Transcription of D first starts in cycle 13 in embryos and then splits into two regions by the 14th cycle. In gastrulation, the transcription of D changes

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    Yy1 Research Paper

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    two specific domains that characterize its function as an activator or repressor. YY1 is a phosphoprotein with a half-life of 3.5 hours.

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    The CRISPR-Cas System

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    inactivate foreign DNA materials such as viral DNA. The foreign DNA is integrated into the CRISPR array. The inserted DNA, known as a spacer, is transcribed from CRISPR loci and translated into short CRISPR RNAs (crRNAs). The crRNA, also known as a guide RNA (gRNA), forms a complex with Cas9. This RNA-Cas9 complex scans for invading DNA materials complementary to the gRNA and cleaves it by Cas9, a protein encoded by CRISPR loci. Cas9 consists of an RNA binding domain, nuclease lobe for DNA cleavage, and

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    Air Bag Essay

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    and the chloroplast share similar effect as the azide. The azide ions interact the β-phosphate of ADP with the residue of the ADP-binding catalytic subunit, βDP, thus occupying the position between the catalytically essential amino acids, β-Lys-162 in the P loop and the “arginine finger” residue, α-Arg-373. This is similar to the y phosphate occupying the ATP-binding subunit, βTP. The βTP substance appears to tighten the side of the nucleotide, enhancing its affinity and thereby stabilizing the state

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    system has revealed that how basic biological research will drive the progress of biotechnologies and therapeutic methods. The story of this novel technique began in 1987 when Japanese researchers Nakata and his colleagues observed a series of 29nt DNA repeats interspaced by five 34nt sequences downstream of the iap enzyme gene in Escherichia coli (19). More and more such repetitive sequences were detected in bacteria and archaea strains over time. The constant findings have sparked research interest

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    adult animal and developmental compensation or early embryonic fatality due to gene disruption could be avoided. This method is irreversible 2.Cre gene can be fused to the gene encoding estrogen receptor(ER). ER translocates to the nucleus after binding to ligand and because Cre is fused to ER, Cre only translocated to the nucleus in presence of ER ligand (tamoxifen). Therefore, the time of

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    Dttp Case Studies

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    important for the ACNase activity of the activated PrrC (Meidler et al,.1999) and it may be required only for stabilizing the activated form. Moreover, dTTP binding was suggested to stimulate the activation, by triggering GTP utilization by its binding (Amitsur et al., 2003) and for the increase in the cellular level of dTTP before the onset of T4 DNA replication and ACNase activation (Blanga-Kanfi et al., 2006).

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