DNA repair

Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder where symptoms resembling aspects of aging are displayed at a very early age (Progeria 101). A genetic disease is an illness caused by one or more abnormalities in the genome, especially a condition that is congenital (present from birth). Genetic diseases are rare and may or may not be heritable. There are thousands of extremely rare genetic diseases, one being Progeria. Progeria affects its

Abstract After a while of searching about progeria, we have found that there are two types of progeria Hutchison-Gilford and Werner Syndrome. They both have the same mutation and symptoms, but they differ in the time the mutation occurs, but still, there is not any specific cure for it yet. Also, we have found that progeria is not related to family disorders’ history like other mutations. The mutation actually happens randomly at a rate of one of four to eight million people. Introduction Progeria

Progeria is a syndrome that is extremely rare which causes premature aging in children. I found this disease very interesting because infants appear perfectly normal at birth but the aging process begins to happen very rapidly as early as 12 months. The young children will start displaying elderly characteristics as the disease progresses. These children will often die from old age diseases such as heart attacks, and strokes or related complications. The mayo clinic website indicates that progeria

Progeria is a little known progressive genetic disorder. This extremely rare, highly fatal, genetic disorder, which comes from the Greek “progeros” meaning “prematurely aging” (Gale Encyclopedia, p. 2202). With the Greek language “pro” is meant to mean before, and “geras” meant for old were combined to create the meaning of this disorder. Commonly referred to as “Progeria”, this disorder is named Hutchinson-Gilford Progeria Syndrome; HGPS for short, was first described in an academic journal by two

Progeria, or Hutchinson-Gilford progeria syndrome, was founded by Jonathan Hutchinson and Hastings Guilford in England in 1886. Progeria is a rare genetic disorder that is found in children who show a rapid growth in age (Sarkar & Shinton, 2001). At first, the child may seem normal at birth, but in the beginning of the first two years the child will start to show a rapid increase of the symptoms of progeria. The main cause for progeria is heart stroke or problems. A child with progeria can live up

In 1886, the first case of Progeria was diagnosed by Dr. Jonathan Hutchinson. Progeria is a pre-mature aging system which is both rare and fatal. He began documenting features of a six year old boy who had symptoms of hair loss and atrophy of skin. Then, in 1897, Dr. Hastings Gilford pronounced Progeria as a clinical entity. The name Progeria comes from the Greek term “progeros" meaning, “prematurely old”. Virtually nothing was known about Progeria 30 years ago. Since it is an extremely rare disease

Several decades of cancer research have identified thousands of mutation causing carcinogens, genetic mutations in DNA repair systems and mutations that cause dysregulation in critical signal pathways involved in cell cycle progression, cell growth and programmed cell death. Human cancers cannot be classified as a single disease because they are each unique on the molecular level. Often the same documented cancer type can inflict two patients with similar symptoms, but the required treatment for

your GG-NER is responsible for genetics diseases such as XP. This disease is mostly linked with the inability to repair cells that contain photoproducts in your DNA that is initiated by UV light. These photoproducts include the (5–5) and (6–6) cyclobutane pyrimidine dimers (CPDs) and the (6–4) pyrimidine pyrimidinone dimers (PDs) that can involve T and C pyrimidines [7]. As these DNA are not repaired due to the lack of NER proteins, a mutation will occur which will substitute a Cytosine base to a

down or monitoring the cell division. The Inhibiting cancer genes “p53” in cells judges the extent of DNA damage.

DNA repair in motion: The mechanical basis of transcription-coupled repair in prokaryotes Proper gene expression is crucial for normal physiological development. Unfortunately, the structural and functional integrity of cellular DNA is constantly at risk by intrinsic and extrinsic factors, from mistakes in metabolic processes to radiation damage. DNA repair pathways are critical processes that address these offenses by maintaining the level genomic integrity necessary for accurate cellular division