Electrophilic aromatic substitution

the Relative Rates of Electrophilic Aromatic Substitution Reaction Justiniano, Priscilla Raiza N. School of Chemical Engineering and Chemistry, Mapua Institute of Technology, Intramuros, Manila, Philippines Experiment No.1, Submitted on August 6, 2011 at N402. Abstract EXPERIMENT NUMBER ONE IS ALL ABOUT THE ELECTROPHILIC SUBSTITUTION OF AROMATIC COMPOUNDS. AROMATIC COMPOUNDS ARE THOSE ORGANIC COMPOUNDS WHICH HAVE BENZENE RING (CYCLOHEXA-1,3,5-TRIENE). AROMATIC COMPOUNDS ARE ALWAYS

The purpose of this experiment was to nitrate methyl benzoate through electrophilic aromatic substitution reaction. Introduction Electrophilic aromatic substitution reactions take place with an aromatic compound, compound with high electron density, and an electrophile a compound which is partially positive. One of the pi bonds in the benzene donates electron to the electrophile which leads to an electron deficient adjacent carbon, carbocation. This carbocation is also known as an arenium ion.

Introduction An organic reaction of aromatic compounds in which a positive ion or other electron-deficient species with a full or large partial positive charge known as an electrophile replaces a hydrogen bonded to a carbon of an aromatic ring is known as an electrophilic aromatic substitution reaction. This reaction is very important for aromatic compounds allowing the direct introduction of groups placements and providing synthetic routes to many important compounds.1 Aromatic rings like benzene are susceptible

In this experiment, an electrophilic aromatic substitution reaction was performed through the addition of a nitro group to bromobenzene. The experiment uses the nitronium ion, NO2+, which acts as an electrophile to replace a hydrogen atom in the aromatic system of bromobenzene. The bromine substituent on the benzene introduces the possibility of isomers from the reaction with the nitronium ion: NO2+ can be positioned in the ortho position (making 1-bromo-2-nitrobenzene), the meta position (making

Electrophilic Aromatic Substitution Objective The objective of this experiment was to illustrate electrophilic aromatic substitution by synthesizing p-nitroanilide (as well as ortho) from acetanilide by nitration. The para form was separated from the ortho form based on solubility properties using recrystallization techniques. Synthetic equations: Physical Properties & Hazards of Reagents/Products: (all taken from Sigma-Aldrich website) Acetanilide MM = 135.16 g/mol Melting point =

Lewis-Acid Catalyzed electrophilic aromatic substitution reactions of thionyl chloride, and benzene. Introduction: Organic sulfoxides, especially diphenyl sulfoxide (Ph2SO), are useful synthetic reagents (Kaczorowska et al., p. 8315). Diphenyl sulfoxide has been used in catalytic oxidation of alkyl sulfides to sulfoxides (Arterburn & Nelson, p.2260). They also play an important role as therapeutic agents. Examples include anti-ulcer, antibacterial, antifungal, anti-therosclerotic, anthelmintic, antihypertensive

benzene through the exchange of one ring carbon for a nitrogen but, is pyridine which is structurally and electronically allied to benzene, also aromatic?. Pyridine is aromatic based on the following facts. The protons of pyridine show chemical shifts in the NMR spectrum that are ordinary of aromatic protons. Furthermore, electrophilic substitutions at pyridine are possible. The nitrogen of pyridine is sp2-hybridized and possesses one lone electron pair. This electron pair is located in an sp2

Preparation of 4-bromoaniline Introduction Aromatic compounds tend to undergo electrophilic aromatic substitutions rather than addition reactions. Substitution of a new group for a hydrogen atom takes place via a resonance-stabilized carbocation. As the benzene ring is quite electron-rich, it almost always behaves as a nucleophile in a reaction which means the substitution on benzene occurs by the addition of an electrophile. Substituted benzenes tend to react at predictable positions. Alkyl groups

he electrophilic aromatic substitution reaction leads to form 1,4-di-t-butylbenzene from the reaction of benzene and t-butyl chloride. The t-butyl cholride is considered not electrophilic enough to react with benzene, so it needs aluminium chloride catalyst to make it strong electrophile. Aluminium chloride is a lewis acid. The chloride atom will be separated from t-butyl chloride and attached to the aluminium chloride to become AlCl4. So, the t-butyl will be a carbocation, and it will be good electrophile

CH 220C – Organic Chemistry Lab Experiment 13: Electrophilic Aromatic Substitution: Nitration of Bromobenzene and Relative Rates of Reaction Rodan Devega Introduction Electrophilic aromatic substitution (EAS) reactions involve the replacement of a hydrogen atom bonded to an aromatic compound by an electrophile. The rate and direction of the EAS reaction depends on the functional groups present on the aromatic compound. The purpose of this experiment was to synthesize bromonitrobenzene by reacting