Excipient

Selection of excipients for Galantamine HBr Orodispersible tablet through drug excipient compatibility study M.Jeevitha* and V.P.Pandey Department of Pharmacy, Annamalai University, Annamalainagar, Chidambaram- 608002, Tamilnadu, India Email : jeevipharma@gmail.com Abstract Galantamine is a clinically useful drug in several neurological problems, including Alzheimer 's disorder. The mechanism of Galantamine HBr is a tertiary alkaloid drug that has been advanced and ordinary in some of countries

Xylitol is an attractive natural sweetener polyol that is commonly used in a variety of pharmaceutical formulations. The most prominent disadvantage of xylitol in pharmaceuticals is its unsuitability for tableting by direct compression. The objective of this study was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced biopharmaceutical performance without altering its polymorphic form. Xylitol was crystallized using antisolvent crystallization

chloride, glyceryl monooleate etc. Conclusion Excipients are essential in the formulation of tablet dosage forms as it ensures successful manufacturing process and quality of the resultant formulation. Proper selection of excipients and their relative concentrations in the formulation is important in development of a successful pharmaceutical formulation. Although excipient are often categorized as inert, preformulation studies can help determine how these excipient influence the stability, bioavailability

Table: 9 Formulation of Metoprolol Succinate Sustained Release Granules S. No. Ingredients F-1 mg/tab F-2 mg/tab F-3 mg/tab F-4 mg/tab F-5 mg/tab F-6 mg/tab F-7 mg/tab F-8 mg/tab F-9 mg/tab F-10 mg/tab 1 Metoprolol Succinate 25 25 25 25 25 25 25 25 25 25 2 Microcrystalline cellulose PH 101 144.5 144.5 142.5 132.5 122.5 112.5 102 94 94 94 3 Hydroxypropyl Methyl cellulose (HPMC K100M) 35 30 32 35 37.5 43.8 46 50 50 50 4 Hydroxypropyl Methyl Cellulose (HPMC K4M) 0 7.5 7 7 7.5 10 10.5 11 11 11 5 Poly

Ideal characteristics of Rapidmelts (31): 1. No water requirement for swallowing purpose but it should dissolve or disintegrate in the mouth usually within fraction of seconds. 2. Provide pleasant feeling in the mouth. 3. Be compatible with taste masking. 4. Leave negligible or no residue in the mouth after oral administration. 5. Dissolve or disperse in the mouth within matter of seconds. 6. Exhibit low sensitivity to environmental conditions as humidity and temperature. 7. Allow the manufacture

Pharmaceutical Excipients Coprocessing Nowadays, there is an increasing demand on multifunctional excipients that replaces the need and use of multiple excipients. There are two ways that can fulfill this requirement, first, the development of new excipients with new chemical entity that has good properties including stability, flowability, compressibility, etc… and is compatible with other excipients in the formulation and with the Active Pharmaceutical Ingredient (API). The second way is to

globally and many nations strive to earn a position in the league. Types of materials used in pharmaceutical Industry The types of materials used in the manufacture of Pharmaceutical products starts with the procurement of materials like binders, excipients that will be added to the core formula. Intermediates will also be added to the

The production and manufacture of Aspirin Aspirin is one of the most consumed painkillers created up to this date due to its reliability and low expense. It is often used to relieve minor aches and pains, reduce fever and as an anti-inflammatory medication. Due to its wide range of uses, the demand for this pharmaceutical is very high. As a result, manufacturers who produce this drug must be efficient in order to reduce the time taken to produce this drug and produce the in very high quantities

Generally, an ANDA sponsor of the topical dermatological product has to undergo multiple review cycles with the FDA before the product gets approved and the sponsor has to wait for a longer time mostly. Even though the ICH CTD, ICH Q8 describes the generation of product development report, it is not still clear to ANDA sponsors how this actually applies. As a result, more internal meetings and discussions between the sponsors and the FDA delays the product approval. One of the ways to overcome these

Acetaminophen is a common pain reliever and fever reducer used to treat conditions such as head, muscle or toothache, as well as colds, fevers, and even arthritis. It is available in a many tablet form to be ingested. These tablets are manufactured by a large variety of pharmaceutical manufactures including a great deal of generic brand companies. These tablets all have the same active ingredient in acetaminophen, yet each hold different inactive ingredients that can impact the overall performance