three different mathematical models, intracellular signaling network model, cell population growth model, and hybrid cellular automata model, proceeded as follows. First, we develop an intracellular signaling network model. We construct simplified cancer-signaling pathway based on prior information about the pathway and experimentally perturb the pathway by various kinase inhibitors. The model defines protein activity or cell viability as a weighted sum of its neighbors, where each weight indicates
INTRODUCTION Experimental research has had a long tradition in psychology and education. The usage of experimental approaches over the past 40 years had been influenced by developments in research practices. The experimental method formally surfaced in educational psychology around the turn of the century, with the classic studies by Thorndike and Woodworth on transfer (Cronbach, 1957). Experimental research is commonly used in sciences such as psychology, medicine, sociology, biology, and so on
services in a cancer resource center was studied. Researchers identified that cancer patients and healthcare professionals may not fully understand the specific purpose and benefits of all therapeutic services available. This study was performed to provide insight on how healthcare professionals should approach the presentation of integrative therapies to their patients. Specifically, their experiment investigated the effects yoga, massage, and Reiki services had on the well-being of cancer patients in
Biologics 1. Traditional Drug-Discovery Methods used trial and error approach where substances introduced to animals or in vitro on the target without any prior knowledge of what would be the result. The effects observed in these cases are examined the treatments for the disease. If a drug gives an effect to a pancreas cells, it can test for insulin related disease like diabetes. 2. Rational Drug Discovery approach starts with a hypothesis, typically the modification of a present known molecule giving a
FIC AIMS Background and problem to be addressed: According to the American Association of Orthopedic Surgeon’s (AAOS), chondrosarcomas are the second leading cause of bone cancers, as well as the most difficult to treat (1). Currently, the only effective treatment includes chemotherapy and wide surgical resection of the bone and cartilaginous tissue surrounding the tumor, which is incredibly invasive and painful for the patient (2). Depending on the location of the tumor, however, surgical resection
suffer from an abnormal amount of stress will skew evidence collected, and make it difficult for scientists to reach conclusions about predicted similar human responses. In reference to the aforesaid example of animal research being done to advance cancer exploration, alternative options are becoming more available. The benefits of using non-animal testing are immense: lack of suffering,
Helicobacter pylori is structurally small, gram negative rods which is microaerophilic in nature and has capability of colonizing regularly in human stomach (Strausbaugh et al., 2002). Due to such colonizing capability, it is regarded as one of the most common bacterial pathogen present in almost 50% of the world’s population (Zhao et al., 2014) and the reason behind such well adaptation or enduring of H.pylori in the Human’s stomach is due to the combined effects of several factors that addresses
support that can help patients actively participate in managing chronic illness. The “Effects of an Internet Support System to Assist Cancer Patients in Reducing Symptom Distress” (Ruland et al., 2013) records the basic findings of a study aimed to analyze the effectiveness of Internet interventions to support patients at different stages of disease and treatment. “A Cochrane review of 24 randomized controlled trials (RCTs) that summarized the effects of different IHCAs for people with chronic diseases
Traditional Drug-Discovery Methods used trial and error approach substances were introduce to animals or in vitro on the target without any prior knowledge of what would be the result. The effects observed in these cases are examined the treatments for the disease. For example, if a drug gives an effect to a pancreas cells, it can tested for insulin related disease like diabetes. 2. Rational Drug Discovery approach starts with a hypothesis, typically the modification of a present known molecule
coverage of the DecisionDX Melanoma testing as experimental and/or investigational and not medically necessary. There is a letter from the carrier to the Castle Bioscience, Inc. dated 06/03/2016 which states: “Procedure code 84999 (DecisionDx-Melanoma) was denied as experimental/investigational services are not a covered benefit… According to Humana's medical coverage policy, DecisionDx-Melanoma for cutaneous melanomas is considered experimental/investigational