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Superparamagnetic iron oxide nanoparticles (Fe3O4: magnetite), as an important and only member of magnetic nanoparticles (MNPs), that approved for clinical use (Watanabe et al., 2013). Magnetite has been widely attracted the intensive research in biotechnology and biomedicine in recent years due to their significant magnetic, electronic, optical and unique features such as low toxicity and biocompatibility properties (Pottler et al., 2015; Lu et al., 2010). Iron oxides nanoparticles (IONPs) such

2.8 MedCalc: MedCalc is a statistical software package designed for the biomedical sciences. It has an integrated spreadsheet for data input and can import files in several formats. 2.9 Test principle for Roche Cobas 6000: UV test Enzymatic reference method with hexokinase. Hexokinase catalyzes the phosphorylation of glucose to glucose-6-phosphate by ATP. Glucose+ATP ______HK___→ G-6-P+ ADP Glucose-6-phosphate dehydrogenase oxidizes glucose-6-phosphate in the presence of NADP to gluconate-6-phosphate

Introduction One in five deaths today is a result of some form of cancer. This terrible disease stems from mutations in body cells, which interfere with the cells’ normal regulation of growth, division, and death. Cells can make occasional mistakes and divide too early or not destroy themselves at the right time (Alberts et al. 2014). The Hayflick limit, described in 1961 by Leonard Hayflick, states that normal human cells can divide for about 50 times (Watts 2011). In cancers, though, this

Sediment samples were taken from 14 stations during the cruise program organized by the Persian Gulf and Oman Sea Ecological Research Institute (PGOSERI), Bandar Abbas, Iran in February 2014. The sediment samples were collected by Van Veen Grab sampler (Hydro-bios, Germany) and then were transferred to sterilized 50 ml tubes, and were kept refrigerated until shipboard processing later that day. The position and depth of sampling stations were recorded (Fig. 1). Selective isolation of actinomycetes

In the current study domain III of PE was deleted and replaced by STXA, by the recombinant DNA technology. STXA was transferred across the cell membrane using domain IIof PE. This domain facilitates the internalization of extracellular compounds into the cytosol, and can translocate heterologous molecules into the target cells(15). Then PE II and STX are connected to fragment variable (Fv) domains of herceptin and create a (single chain) scFv immunotoxin(16). Material and Method 1.1. Material and

The structures of LPSF-33, LPSF-34 and LPSF-35, including both E and Z isomers, were drew using the SPARTAN 08' program [20] and the optimization of each structure was carried out using the RM1 [21] method, available as part of the SPARTAN 08’ program, using internal default settings for convergence criteria. Docking analysis was carried out on Peroxisome Proliferator Activated Receptor (PPAR) Gamma (PDB code: 2PRG). The chosen PPAR structure has been used in another work involving an antidiabetic

10.1. Reducing power by ferric Chloride (FRAP)  About 100 mg of Quercetin (Qu), Rutin (Ru), Silibinin (Si), Qu NPs, Ru NPs, Si NPs, Qu-Ru NPs and Qu-Si NPs (Test samples) were dissolved in 100 ml of methanol to obtain a solution of 1000µg/ml. From this stocking solutions, various working conc. were produced to get concentration of 100, 200, 300, 400, 500 µg/ml with distilled water.  Different concentration of Quercetin (Qu), Rutin (Ru), Silibinin (Si), Qu NPs, Ru NPs, Si NPs, Qu-Ru NPs and Qu-Si

It was known that facial development is a complex process that involves neural crest cells, a population of migratory cells that give rise to the majority of the connective tissue, cartilage and bone in the head during embryogenesis. Additionally, it was acknowledged that defective formation, proliferation, migration and differentiation during the neural crest life cycle could potentially result in craniofacial anomalies (Dixon et al., 2006). The authors utilized previous knowledge to study Treacher

Introduction Cancer is the second leading cause of death in the world (Ferlay et al., 2015) and in recent years there have been many studies to carry out new methods for prevention, diagnosis and treatment of tumor cells and to decrease the side effects of treatment (Tao et al., 2015). In many of these methods a trace of nanotechnology can be found using different type of nanoparticles. In general, nanoparticles have dimensions between 1-100 nm2. Metal nanoparticles are at the center of attention

AntipsychoticsÊpromoteÊtheÊdifferentiationÊofÊoligodendrocyteÊprogenitorcellsÊbyÊregulatingÊoligodendrocyteÊlineageÊtranscriptionÊfactorsÊ1ÊandÊ2. Abstract Aims Oligodendrocyte/myelin abnormalities may be an important component of the pathogenesis found in schizophrenia. The aim of this current study was to examine the possible effects of the antipsychotic drugs (APDs) haloperidol (HAL), olanzapine (OLA), and quetiapine (QUE) on the development of oligodendroglial lineage cells. Main methods CG4