Hemoglobin

invasion occurs, neutrophils rush through the walls of the blood vessels from chemical signals. 5. Nikoleta’s lab results are not normal. Her white blood cell count is far higher than the average threshold, her MCV is lower than normal, and her hemoglobin is drastically lower than the normal threshold level. The only two components that were normal were her red blood cell count and platelet count. As seen in the figures, her red blood cells are of a light pink color, when they should instead be a

blood cells that are elongated and resemble sickles. In sickle-cell disease, mutated hemoglobin binds together to form large masses, which give the red blood cells their sickle shape. The hemoglobin found in this disease is referred to as hemoglobin S (Hb S), as opposed to normal adult hemoglobin, hemoglobin A (Hb A). A point mutation distinguishes the sickle-cell hemoglobin from the normal adult hemoglobin; in Hb S a valine is substituted in place

Sickle Cell Anemia was the first diagnosed disease that was linked to the hemoglobin protein and genetically characterized. In 1910 Sickle cell disease was first characterized when Dr. B. Herrick wrote a report about a patient who suffered from a "strange disease" including such symptoms as asthmatic conditions and blood flow problems including body ulcers. The study led to the locating of a new sickle cell hemoglobin (HbS) that was predicted in the 1940’s by Linus Pauling (Johnson, 1984). Three

Inside the red blood cell is a protein called hemoglobin, which hooks on to the oxygen. People with sickle-cell anemia have abnormal hemoglobin known as hemoglobin S. Hemoglobin S changes the blood cells into the shape of a sickle. These abnormal sickle cells stick to the blood vessel walls causing blockages. These blockages do not allow blood to flow. This is what causes the pain. People get sickle cell disease when a parent has a mutated hemoglobin gene. Their child has a chance of inheriting

RBCs, they clump together while flowing through these particularly small vessels, which causes the loss of oxygen throughout the tissues and organs. This monogenetic disease is caused by a point mutation in the β- globin gene that creates abnormal Hemoglobin S (HbS). There are five different haplotypes for SCD that are classified by their geographical region

Sickle Cell Disease, also referred to as SCD, is a genetically inherited disease that causes abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in red blood cells. This disease currently affects about 90,000-100,000 Americans, a majority being African-American. Because SCD is genetically inherited, it is not contagious. It is inherited when both parents of a child carry the sickle cell trait, also called SCT. SCT and SCD are not the same. In SCT, the person is generally healthy and does

Anemia is a blood condition with decreasing number of red blood cells (RBC) or less than normal levels of hemoglobin (an essential protein that carries oxygen to your tissues and organs) in the blood. Anemia usually occurs when individual does not have enough red blood cells the cells that transport hemoglobin (Hb) throughout your body. [4] Iron deficiency anemia is a common form of anemia that occurs if person does not have sufficient iron in body. Without enough iron your body starts using the

being the packed volume of red cells in whole blood and is measured through integration of total red blood cell count and the mean cell volume of the red blood cells. RBC counts lower than around 0.20 do not generate an HCT. HGB (Hemoglobin Concentration) The hemoglobin is determined using a non-cyanide analytical method from a dilution of whole blood. MCH (Mean

cell disease, is a carrier or they have it themselves. Sickle cell disease is categorized as an autosomal recessive disease. That means in order for one to inherit the disease, they must inherit two recessive alleles for sickle cell disease, or hemoglobin S gene. Having only one recessive allele makes you a carrier. The disorder causes the affected person’s red blood cells to disfigure into a crescent or sickle, which differs from the normal red blood cells that shaped into a doughnut. Sometimes

Thalassemia is a blood disorder transferred through families. It occurs when the body makes less hemoglobin than needed or an unusual form of hemoglobin. Hemoglobin is the protein in red blood cells that carry oxygen. The disorder makes an excessive amount of destruction of red blood cells. This eventually leads to anemia. There are two main types of thalassemia. The first one is Alpha thalassemia. This occurs when a gene or genes related to the alpha globin protein are missing or mutated. It happens