Hemolytic anemia

There are four major types of blood groups that humans have: A, B, AB, and O. An individual’s blood type is determined by the type of antigens that are present in your blood cells; antigens are proteins and cause an immune response on the blood cells. The Rh antigen was discovered in 1940 by Karl Landsteiner and Alexander Weiner with the discovery of the cause of severe jaundice and fetal demise. The Rh antigen was named after rhesus monkeys, because they were the first used in the research of this

Introduction Course Overview Potential lead contamination from drinking water presents a significant health risk. Recent examples of this lead contamination include Flint, Michigan, a city that experienced a large increase in the number of people, especially children, who exhibited symptoms of lead poisoning. A March 9, 2016 article in the Washington Post reported data from the Environmental Protection Agency that indicated approximately 350 schools and day-care centers across the US failed lead

Sickle cell anemia (SCA), an autosomal recessive disease, affects about 250,000 people globally every year. 1 Diagnostic tests are fairly simple because the molecular basis of the disease is noncomplex; the disease is caused by a single amino acid substitution. This substitution changes the conformation of hemoglobin resulting in a “sickled” product. This sickled product is “stickier” than the normal red blood cell creating the diseased state. Currently, treatment options are mostly limited to improving

What is a CRNA? She is your eyes and ears during surgery. She is your advocate when you are unable to speak for yourself. In a cold operating room full of masked faces, beeping monitors, and sharp instruments, she is your safeguard and protector. She remains vigilant, aware of every heartbeat and every breath that you take. She is your lifeline in the midst of uncertainty. It is her trusting eyes and reassuring voice that you see and hear as you enter into the unknown. Little did I know, that I would

Social: Hydroxyurea can cause: excessive tiredness or weakness; fast heartbeat; shortness of breath; on-going pain that begins in the stomach area and swelling. The symptoms associated with hydroxyurea can affect many sufferers in a negative way and lead to a poorer quality of life. The symptoms can lead to depression and emotional distress. In some cases, the symptoms may require hospitalization. As people with sickle cell anaemia are more susceptible to infections, for this reason they may be required

The short life span of RBCs and the damage they cause to tissues can result in the following signs and symptoms: severe abdominal pain, priapism, tissue engorgement, painful swelling of joints and feet, fever, shock, profound anemia, and hypovolemia. Many organs can be affected to include the brain, eyes, bones, liver, spleen, kidneys, penis, extremities, and skin (Ball, J., & Bindler, R., 2015). Pain from sickle cell crises is the most common reasons for hospitalization in

Cell Anemia is a hereditary disease that changes the smallest and most important components of the body. A gene causes the bone marrow in the body to make sickled shapes, when this happens; it causes the red blood cell to die faster. This is what causes Hemolytic Anemia. Older children and adults with sickle cell disease may experience a few complications, or have a pattern of ongoing problems that shorten their lives. The most common and serious complications of sickle cell disease are anemia, pain

species have been isolated in the stomach, gallbladder, intestine, vagina, and skin of healthy persons. The bacteria produce toxins that dissolve cell membranes, causing death of muscle cells, massive spreading edema, hemolysis of red blood cells, hemolytic anemia, hemoglobinuria, and renal failure. Characteristic of this disorder are the bubbles of hydrogen sulfide gas that form in the muscle. Gas gangrene is a serious and potentially fatal disease. Antibiotics are used to treat the infection and surgical

called Rh deficiency syndrome) is the result of a mutation that results in a lack of all Rh antigens. Since these antigens function to maintain the RBC membrane, individuals with this syndrome have abnormally shaped RBCs, leaving them at risk for hemolytic anemia. Rh-null patients are capable of forming antibodies to Rh antigens that can cause transfusion reactions; therefore they must receive blood from other Rh-null individuals. Individuals having the “weak D” phenotype (Du) have low levels of expression

Every slide, every cell and every lab value tells a story. It was July of my first year of hematology research in the US, I was handled a project in transfusion medicine on autoimmune hemolytic anemia. Understanding the concepts of different auto antibodies through a blackboard course at Mayo Clinic fascinated me to look into deeper aspects of this study. Over the past year, my experiments and experience with hematology research has led me into choosing a career in pathology. In quest of a field