Huntingtin

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  • Essay on Understanding Huntington's Disease

    2054 Words  | 9 Pages

    Understanding Huntington's Disease Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder. So if one parent has it, and passes the gene on to a child, that child will develop Huntington's disease if they live

  • Essay on Huntington’s Disease

    990 Words  | 4 Pages

    Near the end of the short arm of chromosome four, there exists a gene which can cause an individual to experience three completely different lives. If the gene is expressed normally, one will never know, as it will not cause the person any harm. However, if the gene simply does not exist, the individual will be born with Wolf-Hirschorn Syndrome, a devastating illness which causes disfigured facial features and mental retardation. (Ridley, 55) Victims of this syndrome rarely live past the age of

  • Taking a Look at Huntington's Disease

    1745 Words  | 7 Pages

    Introduction Huntington’s disease is a neurodegenerative disorder that is inherited in an autosomal dominant fashion. The cytoplasmic protein affected in Huntington’s disease is Huntingtin, coded for by the Huntingtin gene. The mutated version of the Huntingtin protein has several degenerative consequences on the molecular level. These are mainly caused by the elongated chain of glutamines that abberantly interacts with proteins and diminishes their biological functions. The mutated protein also

  • Huntington 's Disease : An Autosomal Recessive Autosomal Dominant Autosomal Disorder

    2037 Words  | 9 Pages

    Abstract Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease. According to aggregation

  • The Disease Of The Middle Ages

    1372 Words  | 6 Pages

    Rooting back to the middle ages the now commonly known Huntington’s disease is the cause of death in one out of 15000 people around the globe. The disease’s existence is documented through history under many different names depending on the amount of information that was gathered through the unusual progression of the disease. The disease was referred to as Chorea initially due to the jerky movements of the patients affected by it. The first thorough description of the disease surfaced in 1872 as

  • Huntington's Disease Essay

    829 Words  | 4 Pages

    at the University College London developed a drug that lowers the deadly protein in Huntington’s disease. Their new drug has successfully lowered the harmful effects of the huntingtin protein, a protein in the brain that can mutate. The drug was also found safe and well-tolerated in its first human clinical trial. Huntingtin protein is found in every human gene. A gene is a section of DNA made of four different nucleotide bases called adenine, cytosine, guanine, and thymine. At the beginning of this

  • How to Control Huntington’s Disease

    875 Words  | 3 Pages

    dominant manner, means that the inheritance of a single copy of the mutant huntingtin allele containing an expanded CAG repeat region in exon 1 (>36 CAG repeat) causes the disease. Translation of the mutant allele mRNA yields the mutant huntingtin protein (mHtt) containing an expanded polyglutamine region near the amino terminus, which favor protein cleavage and accumulation of the N-terminus in the nucleus. N-terminal huntingtin affects transcription of subsets of genes. Early in HD progression, levels

  • Essay Huntington's Disease

    1113 Words  | 5 Pages

    Huntington's Disease Background Huntington's disease is inherited as an autosomal dominant disease that gives rise to progressive, elective (localized) neural cell death associated with choleric movements (uncontrollable movements of the arms, legs, and face) and dementia. It is one of the more common inherited brain disorders. About 25,000 Americans have it and another 60,000 or so will carry the defective gene and will develop the disorder as they age. Physical deterioration occurs over a period

  • Huntington Disease Case Study

    594 Words  | 3 Pages

    segment is repeated 10 to 35 times within the gene. In people with Huntington disease, the CAG segment is repeated 36 to more than 120 times. An increase in the size of the CAG segment leads to the production of an abnormally long version of the huntingtin protein. The elongated protein is cut into smaller, toxic fragments that bind together and accumulate in neurons, disrupting the normal functions of these cells. The dysfunction and eventual death of neurons in certain areas of the brain underlie

  • Reducing Huntington's Disease

    1583 Words  | 7 Pages

    Overview Huntington’s Disease is a dominant, autosomal, neurodegenerative disease that results from excess CAG repeats on the human chromosome 4. These CAG repeats code for a protein named Huntingtin, and patients of Huntington's Disease have a mutated form of it. Symptoms begin to appear in one’s middle ages and continue to progress over a span of about 20 years. It leads to loss of mental ability and muscle coordination, as well as increasing one’s vulnerability to depression. Those who develop

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