Immunofluorescence

Recent findings have focused on developing effective proteasome inhibitors as anti-proliferative agents because previous reports strongly suggest that abnormal or impaired functions of proteasome aggravate the accumulation of aberrant proteins in cells, which consequently stimulate apoptosis in cells (Chhangani et al., 2013; Chhangani and Mishra, 2013; Huang and Figueiredo-Pereira, 2010). Although, the role of proteasome is well-established in clearance of misfolded aggregation of proteins linked

Cells are the major functional unit of living organisms. Each component of a cell plays a vital role and the cytoskeleton is just as important as any other organelle. Without the cytoskeleton a cell would have no structure. The cytoskeleton is composed of microtubules, actin filaments, and intermediate filaments, which are necessary for reproduction, maturation, and survival of plant cells (1). The primary function of the cytoskeleton is to provide framework for the cell and help support development

Atkinson, P., Wise, A., Flynn, B., Nayagam, B., Richardson, R. (2014). Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs. PLoS ONE9(7). • Purpose: The purpose of this study was to determine whether or not degenerated hair cells within the cochlea could be regenerated using the introduction of ATOH1. ATOH1 is a transcription factor that is known to be essential to hair cell growth and development. Typically, damaged hair cells within the cochlea result

Influenza Virus “Flu” Jenny Millares Keiser University MCB2000C Professor Algevis Wrench Influenza Virus “Flu” Influenza, also known as ‘the flu’, is a viral infection that tends to extent through societies between November and April every year, with a highest number of cases occurring in January and February. It is a respiratory illness that causes chills, high fever, body aches, and cough, but sometimes, its complications can be deadly. “About 5% of the population will contract the flu each

From the first outbreak in DRC in 1976 to the recent epidemic in West Africa (2013 - 2015), there has been a considerable amount of research done to further the development of the diagnosis and therapeutic strategies of the Ebola virus. Methods for detecting the virus have improved drastically. From the initial stage of simply identifying the virus as a whole, diagnosis can now define the specific species of the virus. Diagnosis processes developed over the years are those that involve Cell Culture

with the virus and now has an immune response. It has one screening test and two confirmatory tests to find antibodies to MERS-CoV. The screening part is called enzyme-linked immunosorbent assay (ELIZA) and the confirmatory tests are called immunofluorescence assay (IFA) and microneutralhzation assay to check for the positive result. (Middle East Respiratory Syndrome,

The aim of this study is to do initial characterization in bone marrow cell extract (BM soup). Our results demonstrated that 1) BM soup contains many kinds of protein factors secreted by bone marrow cells, such as growth factors, cytokines; 2) proteins are the active ingredients responsible for its therapeutic action. To reduce the irradiation damage of salivary glands, many approaches are being tested. The best approaches are to spare salivary glands from the high dose co-irradiation as much as

Introduction Lyme disease has been the most commonly reported vector-borne illness in the United States since the Centers for Disease Control and Prevention started reporting it in 1991 [1]. It should be noted that Lyme disease does not occur everywhere in the US, and is heavily concentrated in upper Midwest and northeast United States [1]. This report has been compiled to provide recommendations for antimicrobial prophylactic treatment of Lyme disease once a patient encounters a tick bite. Lyme

Lyme disease has been identified as an infection surrounded by complications, starting from its discovery to diagnosis. The Lyme infection was discovered first during the mid-1970, following the attribution of juvenile arthritis outbreak to this disease near Old Lyme, Connecticut. The naming of the disease was established in 1977, although the complications of the causative agent lasted an additional five years, after which medical scientists identified the deer tick midgut Borrelia burgdorferi spirochete

Approved By: In accordance with IACUC Protocol # Rohitha Moudgal NBB 495A Fall 2015 Honors Proposal Investigating a Genetic Interaction Between LSD1 and Hyperphosphorylated Tau in a P301S Mouse Model Background Alzheimer’s disease is the most common form of dementia and is characterized by the degeneration and death of brain cells that causes a loss of mental function. Although neuronal loss is not considered a normal part of aging, age is a significant risk factor for Alzheimer’s disease (AD)