Immunofluorescence

Attack of Progerin: “Lamins are intermediate filament proteins forming a network in the inner nuclear membrane” (ubcmj.com). They are essential to the body, "maintaining the structural integrity of the nucleus" and have a hand in chromatin organization, DNA replication/transcription, and RNA processing (ubcmj.com). A common malfunction that occurs in HGPS patients is a heterozygous single cytosine to thymine point mutation in exon 11 at position 1824 of the coding sequence. Although there is no

Catch scratch fever disease is a bacterial infection caused by Bartonell henselae bacteria. This disease gets in name because people contract it from cats. It is one of the most common bacteria in the world. Most infections usually occur after scratches from domestic or feral cats, especially kittens. CDS occurs whenever cats and fleas are around. Common symptoms include fever; enlarged lymph nodes, scab or pustule at the scratch site. In the United States, most cases occur in the fall and winter

Protozoans Scientific Name Toxoplasma gondii is attributed to foodborne illnesses but can cause an infection with a common parasite that is found in cat feces and contaminated food hence foodborne illnesses. “Although, Toxoplasma gondii was first observed in rodents by Nicolle and Manceaux in 1908” (History of Discovery 2006), it was not until 1932 that T. gondii was identified as an infectious disease. Today, Toxoplasma gondii has become a worldwide protozoan that infects the human host and can

Dictyostelium discoideum--also known as slime mold--is an amoeba, whose natural habitat is soil and decaying leaves found in the deciduous forest (key paper). This organism’s life cycle consists of a unicellular phase and a multicellular phase. During the unicellular phase, the amoeba feeds on bacteria and yeast, and reproduces through binary fission. Upon starvation conditions, D. discoideum amoeba collect into aggregates. Cell differentiation would occur at this point to eventually create a multicellular

BACKGROUND Cancer results from abnormal, unregulated cell growth which can create physiological impairments in body tissues (1). Two adverse characteristics of cancer cells include the ability to invade other tissues and the inability to die (2). Cells generally become cancerous due to changes in gene expression and subsequent errors in protein function (2). These faults in genes and physiology can be caused by mutations which can result from exposure to carcinogens. One of the most common substances

Pathophysiology The COL7A1 gene contains the instruction manual for making proteins that are used for strengthening and supporting the connective tissue in the body which includes tendons, ligaments, bones and skin. “The proteins produced from the COL7A1 gene, called pro-α1 (VII) chains, are the components of type VII collagen.” (http://ghr.nlm.nih.gov/gene/COL7A1) When three pro-α1 (VII) chains twist together, they form a triple-stranded molecule called a procollagen, these molecules are secreted

HIV/AIDS exploded into the public conscience in the early 1980 's. Many of the earliest cases were reported in the media as being the result of homosexual sex practices. In 1983, an AIDS Hotline was published by the United States CDC disseminating information regarding the disease and it was reported that cases were discovered in female patients who had sexual contact with men with AIDS. By September of that year the government had published the known routes of transmission of this new virus

A. Summary Begin your critical analysis with a brief summary of the article (4-6 sentences). (5 points) Researchers found the Zika virus is a member of the Flaviridae family and is transmitted to humans by, mosquitoes. Although these research results are promising, it is difficult to determine whether this experiment really did ZIKV virus is a members of the Flaviridiae family or different family. Was the experiment of the ZIKV conduct appropriately to all animal? And although this research promising

A side observation during initial attempts of applying SV40 T-antigen in two microalgal species Ahmed E. Gomaa, Sameh Elsawy, Sang MiSun, Seung Hwan Yang, GyuhwaChung* Department of Biotechnology, Chonnam National University, Chonnam 550-749, Republic of Korea Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Gyeonggi 449-728, Republic of Korea *Corresponding author Gyuhwa Chung E-mail: chung@chonnam.ac.kr Phone: +82-61-659-7302 Fax: +82-61-659-7309 Running title: Effects

DNA Double Strand Breaks (DSBs) are valuable when controlled, but potentially fatal when not – the programmed DSB is an essential part of particular cellular processes (e.g. VDJ switch recombination during immune system development and during homologous recombination in meiosis and mitosis), but an unprogrammed DSB is also considered the most lethal type of lesion for a cell (Sedelnikova et al., 2003). Cells are confronted with DNA damage due to a variety of stimuli under normal physiological conditions