Immunofluorescence

Abstract Endoplasmic reticulum (ER) stress response may be mediated by HRV16 nonstructural proteins 2B, which share similar characteristics to CVB3 2B. To understand whether HRV16 2B induces an ER stress response, a HRV16 2B fusion protein with GFP were generated and its effects on ATF6a (activating transcription factor 6a), IRE1 (Inositol-requiring enzyme 1), and PERK (PKR-like ER protein kinas) expression in BHK cells were determined. The results showed that HRV16 2B induced significantly high

Introduction Parkinson's disease (PD) is an adult-onset neurodegenerative disorder, concomitant with neuronal loss predominantly in the substantia nigra pars compacta (SNpc) and inclusions comprising of the synaptic protein, α-synuclein (α-syn). Recent developments have advanced our understanding on the multitude of inter-mingled deleterious factors contributing to PD neuropathological aetiologies. These encompass “cell autonomous” processes, for instance, autophagy, and mitochondrial dysfunction

Pathophysiology of the human immunodeficiency virus Nancy R. Calles, MSN, RN, PNP, ACRN, MPH Desiree Evans, MD, MPH DeLouis Terlonge, MD Objectives 1. 2. 3. 4. 5. Provide an overview of the healthy immune system. Describe the human immunodeficiency virus (HIV). Describe the major components of the HIV life cycle. Identify the various HIV types and subtypes. Discuss HIV’s effects on the immune system. Overview The human immunodeficiency virus (HIV) is a retrovirus belonging to the family of lentiviruses

Zagazig University Faculty of Medicine Clinical Pathology Department Association of STAT4 Gene Single-nucleotide Polymorphism with Systemic Lupus Erythematosus Thesis Submitted for partial fulfillment of M.D. degree in clinical pathology By Marwa Abd El-Monem Mohamed Ateya MB.B.CH. Ass .lecturer of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Lamiaa Abd Al-wahab Mohammad Professor of Clinical Pathology Faculty of Medicine Zagazig University Prof. Dr. Asmaa

HIV The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen,

A Research about Human Immunodefiency Virus I. HIV or Human Immunodeficiency Virus is a lentivirus responsible for gradually destroying the human immune system, and subjecting it to various invincible opportunistic infections. It is the most complex virus ever encountered by mankind. Many of its mysteries have been unleashed through persistent research and studies. While many, are yet to be revealed. II. There are a lot of things to know about this virus. A. History of HIV

Abstract Myelin and oligodendrocyte dysfunctions have been consistently found in patients with schizophrenia. The effect of antipsychotics on myelin disturbances is unknown. The present study examined the effects of quetiapine on oligodendrocyte regeneration and myelin repair in a demyelination animal model. C57BL/6 mice were fed with cuprizone (0.2% w/w) for 12 weeks to induce chronic demyelination and oligodendrocyte degeneration, after which cuprizone was withdrawn to allow recovery. Quetiapine

Review of literature: Acute respiratory infections are a major cause of human disease and are one of the most important causes of child mortality throughout the globe. Though there are considerable variations in infantile mortality, according to World Health Organization, the lower respiratory tract infections are the second most important cause of death among children < 5 years of age. (Carolina et al., 2012) Respiratory syncytial virus is most frequently detected in childhood illness. Factors

Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model Abstract Studies have implicated astrocytic dysfunction in Alzheimer's disease (AD). However, the role of astrocytes in the pathophysiology and treatment of the disease is poorly characterized. Here, we identified astrocytes as independent key factors involved in several Alzheimer-like phenotypes in an APP/PS1 mouse model, including amyloid pathology, altered neuronal and synaptic

50 Celiac Disease Dascha C. Weir, MD Ciaran Kelly, MD Celiac disease (CD) is an immune-mediated enteropathy secondary to permanent sensitivity to wheat gluten and related proteins in rye and barley. It results in characteristic histologic changes consisting of inflammation, crypt hyperplasia, and villous atrophy of the small intestine in genetically susceptible individuals. Significant variability in the clinical presentation of CD in the pediatric population complicates recognition of