In situ hybridization

Cervical cancer is the fourth most common cancer in women, attributing to 266,000 deaths per year worldwide, a female gynecological cancer mortality rate second only to breast cancer. Although the human papillomavirus (HPV) has been implicated in 90% of cervical cancer cases, not all causes of cervical cancer are known, representing a critical barrier to progress in therapeutic development. Current therapies include a combination of hysterectomy and radiation or chemotherapy, all of which have significant

evaluation of the lymph node is inadequate, or the findings on cytologic and sonographic evaluations are divergent [43–45]. HPV detection may be performed by means of a variety of methods, including p16 as a surrogate immunohistochemical marker, in situ hybridization and/or polymerase chain reaction detection of viral DNA or RNA [4,46–48]. Chandan et al found glucose transporter-1 immunostaining to be a useful adjunct in differentiating BrCC from cystic metastasis of H&N SCC [49]. Pai et al reported that

couples should be not be permitted to use preimplantation genetic diagnosis to select an embryo in any circumstance. Preimplantation genetic diagnosis (PGD) uses genetic analysis technologies such as PCR, comparative genomic hybridization, or fluorescence in-situ hybridization to ultimately select an embryo based on the presence or

SUMMARY OF QUALIFICATIONS Detail-oriented and independent scientist with research experience in human aging and genetic diseases, pursuing a variant scientist role in clinical genomics and genetic counseling  Hands-on experience in human genetics, interpretation of genomics data, and validation of disease mechanism  Efforts to comply with various regulations including HIPAA and IACUC  Strong analytical and problem-solving skills, as well as excellent communication skills to work with high-caliber

proteins in large amount. Several approaches can be envisaged to address the function of a gene. The techniques of molecular biology and biochemistry allowing for example to localize the expression of a gene or its product (Northern, western, in situ hybridization, immunofluorescence, etc.), to determine the structure of the protein (NMR, crystallography ...) or to find partners proteins (double hybrid, immunoprecipitation ...) give important information on the function of a gene (V Ecochard -2011).

determine if the individual has the characteristics of the typical person has if is affected by the disorder. * A blood test called (Fish) can help to confirm the diagnosis. This technique is made in the laboratory and the lab name is fluorescent in situ hybridization (Fish). The cause of the William Syndrome is the deletion of part of the long chromosome number 7 and the deletion is included Elastin Gene. After the blood test is done if the individual has only one copy of the Elastin Gene in one of the pair

Timely administration of appropriate antibiotics is essential for decreasing hospital mortality in patients with sepsis12. Kumar et al. demonstrated that with each hour delay, there is a 7.6% decrease in survival. Moreover, delaying appropriate antibiotics can increase healthcare costs, length of stay and antimicrobial resistance13, 14. Traditional methods of microbial identification have time concerns. Most laboratories take 48-72 hours to determine microorganisms’ susceptibility testing10, 15.

The use of IVF and Pre-Implantation Genetic Diagnosis (PGD) 1. Pre-Implantation Genetic Diagnosis, or PGD, is a procedure that people can go through to avoid passing down inheritable conditions that can have dangerous long-term effects on their children. It involves screening the mother’s embryos by In-vitro Fertilisation (IVF) for mutations, and selecting healthy embryos for further treatment. This can ‘increase the chance of a genetically normal pregnancy and the chance of having a healthy baby

A genetic disorder is an illness that is caused by one or multiple abnormalities in the genome. Genetic disorders are not unusual, however when a genetic disorder occurs it usually happens in one and every thousand or million persons. Sometimes genetic disorders can or cannot be heritable, meaning passed down from the parents to their offspring. Often times the parents are unaware that they can carry over a genetic disorder to their offspring. When genetic disorders that does not occur from the

Tina Nguyen BIO 100 - 07 30 November 2015 Transmission and Survival of Foreign Genetic Material The biological findings of Charles Darwin contributed to revolutionizing modern understanding of evolution and genetics through the comparison of biodiversity and the trending similarities and differences among members of shared lineage. Darwin's observation of how the environment impacted the evolution of species as they adapted to their surroundings led to the understanding of how new environments may