In vivo

Perhexiline maleate, an anti-anginal metabolic modulator, blocks the mitochondrial enzyme carnitine palmitoyltransferase 1 (CPT1) and to a lesser extent CPT2, which triggers causes a shift in myocardial substrate utilization from long chain fatty acids to carbohydrates, leading to the increased glucose and lactate utilization and increased ATP production for the same O2 consumption and consequently improves myocardial efficiency. CPT1 and CPT2 are mitochondrial enzymes which oxidize long-chain fatty

Plants have always been the prominent source of traditional products for the therapeutic purposes of human being. In the nineteenth century, before the initiation of synthetic organic chemistry medicinal plants were the key source of physiologically active substances that were exploited for therapeutic purposes. Many people in the developing countries have great faith on the medicinal plants for their health care although having the modern medicines. The world health organization (WHO) has comprised

Dihydrodaidzein Description: IC50: Dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. As an estrogen receptor agonist, dihydrodaidzein activates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations. Daidzein, an isoflavonoid phytoestrogenic compound, is found in in soybeans, clover, pea pods, kudzu, and other legumes. In vitro: Prostatic

Monastrol is a potent, reversible, and cell-permeant inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), inducing the formation of monoastral spindles in cell-based assays with an IC50 value of 51.3 μM and blocking basal ATPase activity in vitro with an IC50 value of 6.1 µM. Monastrol arrested cells in mitosis without effects on other motor proteins and tubulin, therefore, it does not interfere with microtubule-dependent processes. Monastrol triggers the activation of the spindle

Targeted disruption of CTRP drastically reduced the gliding motility of ctrp ookinetes and abolished the midgut epithelium infectivity and no oocysts were seen produced in vivo study (Yuda et al., 1999). Similarly, targeted disruption of CDPK3 generated mutant ookinetes that were immotile and failed to invade the midgut epithelium in vivo (Siden-Kiamos et al., 2006). For the successful invasion of midgut epithelium by the ookinete, they must attain gliding motility before to shift any cellular transformation

Relevance of the study The identification of lysine succinylation is of very much importance in my area of research because lysine modification is thought to be in the malaria parasite Plasmodium falciparum (Miao et. al, 2013). One of the most common post-translational modifications for the malaria parasite are lysine phosphorylation, acetylation, methylation, and lipidation (Doreing et. al 2015). The identification of post-translation modification is a very important process, because the post-translation

Parallel to proteins, the free amino groups of nitrogen bases of nucleosides and nucleotides under alkaline pH conditions are also prone to the Maillard reaction (Reihl, O. et al, 2004). DNA reacts with reducing sugars (glucose, fructose, ribose etc.) and advances via Amadori reaction leading to the formation of irreversible complexes known as DNA-advanced glycation end products (DNA-AGEs) (Bidmon, C. et al 2007; Frischmann, M. et al 2005). Various report suggested that nucleobases possessing amine

Treatment Rationale Trauma Focused Cognitive Behavioral Therapy was developed to help children and their caregivers overcome the negative effects of traumatic life events such as the sudden and unexpected loss of a loved one, bullying and avoidant personality. Alan Turing was repeatedly bullied in school. He also lost a significant figure in his life. Both circumstances have detrimental effects and can cause anguish and avoidance. TF-CBT can help ease anxiety, fears, stress, and other emotions associated

Mucosal candidiasis is a fungal infection that has become more common as increasing numbers of people undergo long-term immunosuppressive therapies, antibiotic treatments or use of prescription drugs that reduce salivary function or changes in vaginal environment. It is estimated that several millions of people across the world acquire oral candidasis each year, yet the choices in antifungal drugs therapy are limited and these drugs result in development of drug resistant strains. The detailed functional

Introduction Metabolic syndrome (MS) is a controversial clinical entity that appears with large phenotypic variations in people with an endogenous predisposition. It was determined genetically and influenced by environmental factors (Lopez, 2007). Women who exhibit aspects of MS before pregnancy, such as obesity, chronic hypertension, diabetes mellitus and dyslipidemia, have a high risk of placental dysfunction and even fetal death (Gallo et al., 2010). Caudal regression syndrome (agenesis or hypoplasia