Induced pluripotent stem cell

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  • Progress in the Reasearch on Induced Pluripotent Stem Cells

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    study in stem cell research. They reprogrammed mouse skin fibroblasts by introduction of four transcription factors, Oct3/4, Sox2, Klf4 and c-Myc and generated cells almost indistinguishable from ES cells. They named these cells induced pluripotent stem cells (iPSCs) (Takahashi K., et al., 2006). An year later, James A. Thomson et al. replaced Oct4 and oncogenic c-Myc with Lin28 and Nanog decreasing the risk of cancer formation (Yu J., et al., 2007). We need to take into consideration that cell types

  • Analysis Of Adipose Derived Induced Pluripotent Stem Cells

    4532 Words  | 19 Pages

    Analysis of adipose derived induced pluripotent stem cells (iPSC’s) microRNA (miRNA) expression profile over multiple passages and pancreatic β-cell miRNA expression profile post differentiation from iPSC’s. Simplified title Improvement of stem cell differentiation to pancreatic β-cell for transplantation into diabetics. 2) Project summary Ethical concerns regarding the use of embryo-derived embryonic stem cells (ES), and the immune response elicited by differentiated ES cells, are being circumvented

  • Can Skin Dermal Papilla (DP) Cells Differentiate into Induced Pluripotent Stem Cells?

    578 Words  | 3 Pages

    (DP) cells can differentiate into induced pluripotent stem cells (iPSCs) by using the transcription factor, OCT4, instead of using all four transcription factor, OCT4, Sox2, Klf4, and c-Myc, which are usually used to differentiate somatic cells into stem cells. The scientists came up with the question because two out of the four transcription factors, Klf4 and c-Myc, are oncogenic gene, thereby it is best to replace these genes with other safer alternatives. Reprogramming cells into induced pluripotent

  • Induced Pluripotent Stem Cells Essays

    1185 Words  | 5 Pages

    Describe:- (i) how induced pluripotent stem cells (iPSCs) are isolated (ii) how iPSCs can be used to study human development (iii) how iPSCs can be used to model human disease and to develop therapies for degenerative disease i) iPSCs are adult stem cells that have been genetically reprogrammed to behave like the pluripotent stem cells found in embryos, i.e. can differentiate into any cell type in the human body. This was first completed successfully in mice in 2006 by Shinya Yamanaka and his

  • Induced Pluripotent Stem Cells Essay

    1759 Words  | 8 Pages

    Induced Pluripotent Stem Cells: Methods of Production, Characterization and Applications to Medicine Student’s Name University Induced Pluripotent Stem Cells: Methods of Production, Characterization and Applications to Medicine Introduction By definition, induced pluripotent stem cells (iPSCs) are somatic cells with preprogrammed features (Kamath et al. 2017). In essence, they are often modified to mimic embryonic stem cells through the expression of ectopic factors linked to gene

  • Induced Pluripotent Stem Cells And The Maintenance Of Neural Crest Stem Cell

    1331 Words  | 6 Pages

    Induced Pluripotent Stem Cells—Derived Neural Crest Stem Cells and the maintenance of Neural crest stem cell multipotency Stem cells are unspecialized cells, which have the potential to develop into several different cell types—muscle cells, brain cells, skin cells, or red blood cells—during early development. Stem cells continuously divide in order to replace other cells. As stem cells divide, they have the potential to develop into a specialized cell or remain a stem cell. Induced pluripotent

  • Stem Cells Essay

    1746 Words  | 7 Pages

    Introduction The use of stem cells can advance drug development, knowledge of disease, patience specific disease treatment, and can bypass the limits of mouse-models for research. According to the National Institute of Health (1), stem cells are unique in the following ways: they can divide and renew themselves for long periods, they are unspecialized, and they can give rise to specialized cell types. The uniqueness of these stem cells allows for the testing of new drugs, cell-based therapies and the

  • The Ethical Use Of Embryonic Stem Cells

    694 Words  | 3 Pages

    Stem cells not only exist in developing embryonic cells but also in the adult nervous system of all mammalian organisms which include humans. Stem cells can also be derived from developing mammalian nervous system. Embryonic stem cells have vast possibility in the field of tissue engineering and regenerative medicine as they have the capacity to produce each type of cell and tissue in the body. On paper, it could revolutionize the way human diseases and organ transplants are treated by creating any

  • Describe How Mature Somatic Cells Can Be Reprogrammed to Become Pluripotent

    991 Words  | 4 Pages

    technology, it is possible to reprogram matured somatic cells in pluripotent cells by introducing factors that can induce cell in situ reprogramming. (1) This technique is highly useful in medicine, including acting as a model for drug and clinical testing, development of drugs. Pluripotent stem cells are the stem cells that can only differentiate into a limited range of differentiated cells. (2) They have the ability to give rise to all somatic cells from ectoderm, mesoderm and endoderm, as well as gametes

  • A Research Study On Stem Cell Research

    1324 Words  | 6 Pages

    like this. He knows that stem cells could help cure him from his misery, so he has been fighting and fighting for stem cell research to be fully funded in America. Stem cells are cells that have the skill to change into any type of cell in the human body (Lewis). These cells could be put anywhere ill in the body to make it healthy again. Imagine all of the people with chronicle diseases and cancer being able to have hope for being happy and healthy again. Also, these stem cells can fix