Kaposi's sarcoma-associated herpesvirus

Disease and Pathology Human Herpesvirus 8 (HHV-8) is commonly known as Kaposi’s sarcoma-associated herpesvirus (KSHV). “A disease will become an emerging infectious disease when the incidence in humans has increased in the past two decades” (Centers for Disease Control and Prevention). KSHV/HHV-8 has been around since 1872, it was first discovered by Dr. Moritz Kaposi (MacGill). This virus is known as one of the human cancer viruses, it causes Kaposi’s sarcoma (KS), primary effusion lymphoma and

discovered because of the AIDS epidemic, but I didn't know that Kaposi Sarcoma was around longer than that. I learned that in 1872, Mortiz Kaposi described the cancer in Europe as blotches on the skin, which targeted older men because they are immunosuppressed. I learned that this is because, as you age your immune system goes down. I learned that in the 80’s there was no diagnosis of HIV so if someone show up with Kaposi Sarcoma, the doctors would use this as a sign that they have HIV.

Castleman’s Disease What is it? Castleman 's disease is a rare condition characterized by benign, non-cancerous, growths that develop in the lymph node tissue throughout the body. With the exception of the central nervous system (CNS), lymph nodes may be found in every area of the body. Most often, these growths occur in the chest, stomach, and/or neck, but may also be found in the armpit, pelvis, and pancreas. Usually the tumors represent abnormal enlargement of the lymph nodes normally found in

Primary effusion lymphoma (PEL) is caused by clonal expansion of human herpesvirus 8 (HHV8; also known as Kaposi’s sarcoma-associated herpesvirus) infected B cells (Nador et al., 1996). HHV8 is an oncogenic herpesvirus that pathogenically infects endothelial cells and B lymphocytes. Besides, PEL is also implicated in the pathogenesis of Kaposi’s sarcoma and multicentric Castleman’s disease (Carbone et al., 2009; Cai et al., 2010). The replicative cycle of HHV8 exists as latency and lytic replication

The deadly disease, known as Kaposi Sarcoma, was first discovered by Moritz Kaposi and later named after the discoverer himself. Moritz Kaposi was a Hungarian physician and dermatologist and he first discovered the disease in 1872 describing it as an idiopathic multiple pigmented sarcoma of the skin. He studied the affliction on five elderly male patients. Moritz continued to describe the various characteristics of the disease including nodules developing on the skin, mainly on the hands and feet

Oncology is the study of virus caused cancers. These cancers include Adult T-cell Leukemia, Kaposi’s Sarcoma, Cervical Carcinoma, Hepatocellular Carcinoma, and Burkitt’s Lymphoma. Viruses that can cause cancer are known as oncoviruses. Known oncoviruses are: Hepatitis B and C (HBV and HCV, respectively), Human T- Lymphotropic Virus (HTLV-I), Human papillomavirus (HPV), Kaposi’s Sarcoma- Associated Herpesvirus (HHV-8), and Epstein- Barr Virus (EBV). Viruses, after entering a host cell, integrates

as it takes advantage of the weakened immune system of the patient in order to survive in the host body. Studies conducted to understand the epidemiology and pathogenesis of KS show that globally, there is an uneven distribution of Kaposi’s sarcoma-associated herpesvirus (KHSV). Results show that areas, such as sub-Saharan Africa, have a higher prevalence of the endemic type KS. This type of KS tends to occur in younger people and usually affects the lymph nodes and other organs. However, Western Europe

virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) establish lifelong persistent infection in the host and are capable of causing several lymphomas and neoplasms. Gammaherpesviruses have two distinct phases in the life cycle: lytic replication and latency. Lytic replication is cleared by the immune system, the virus evades detection by the immune system and maintains a lifelong persistence in the host by establishing latency. Viral latency in B cells is the critical event associated with tumorgenesis

Human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), is caused by an excessive proliferation of spindle cells thought to have an endothelial cell origin. Despite their heterogeneity, the tumors are predominantly composed of KSHV genomic material with Immunohistochemical markers of both lymphoid, spindle, and endothelial cells. HHV-8 is strongly associated with all subtypes of Kaposi's sarcoma (KS), multicentric Castleman disease,

able to discover HIV/AIDS and the causes of Kaposi 's Sarcoma and Pneumocystis pneumonia of homosexual men in July 1981, following the report of these cases of PCP and cases of other rare life-threatening opportunistic infections and cancers in America we began to recognize the importance of being aware of HIV/AIDS. These articles outlined major events in the AIDS epidemic. The thing that stood out to me is the information on Kaposi 's sarcoma. This cancer was so rear that it may be missed and not